Captodiame hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573582

CAS#: 904-04-1

Description: Captodiame hydrochloride is an antihistamine used as a sedative and anxiolytic. Captodiame may be helpful in preventing benzodiazepine withdrawal syndrome in people discontinuing benzodiazepine treatment.


Chemical Structure

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Captodiame hydrochloride
CAS# 904-04-1

Theoretical Analysis

MedKoo Cat#: 573582
Name: Captodiame hydrochloride
CAS#: 904-04-1
Chemical Formula: C21H30ClNS2
Exact Mass: 395.1508
Molecular Weight: 396.05
Elemental Analysis: C, 63.69; H, 7.64; Cl, 8.95; N, 3.54; S, 16.19

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AY 55074, Captodiame HCl, Captodiame hydrochloride, Captodiamine hydrochloride, Covatin hydrochloride, Covatine, Covatix hydrochloride, N-68, Suvren

IUPAC/Chemical Name: 2-(p-(Butylthio)-alpha-phenylbenzylthio)-N,N-dimethylethylamine hydrochloride

InChi Key: IQCZDPRPOLRNQX-UHFFFAOYSA-N

InChi Code: 1S/C21H29NS2.ClH/c1-4-5-16-23-20-13-11-19(12-14-20)21(24-17-15-22(2)3)18-9-7-6-8-10-18;/h6-14,21H,4-5,15-17H2,1-3H3;1H

SMILES Code: c1([C@@H](c2ccccc2)SCC[NH+](C)C)ccc(SCCCC)cc1.[ClH-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 396.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Baandrup L, Ebdrup BH, Rasmussen JØ, Lindschou J, Gluud C, Glenthøj BY. Pharmacological interventions for benzodiazepine discontinuation in chronic benzodiazepine users. Cochrane Database Syst Rev. 2018 Mar 15;3:CD011481. doi: 10.1002/14651858.CD011481.pub2. Review. PubMed PMID: 29543325.

2: PENTNEY BH, BROTHERWOOD RW. Captodiame in anxiety states in general practice. Practitioner. 1960 Aug;185:218-21. PubMed PMID: 14431646.

3: ABBOTT LG. Neurodermatoses and captodiame. Aust J Dermatol. 1960 Jun;5:187-90. PubMed PMID: 13791384.