WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 407999
CAS#: 661482-39-9
Description: LAF-153 is a reversible Methionine Aminopeptidase‑2 (MetAP-2) Inhibitor.
MedKoo Cat#: 407999
Name: LAF-153
CAS#: 661482-39-9
Chemical Formula: C18H34N2O6
Exact Mass: 374.2417
Molecular Weight: 374.478
Elemental Analysis: C, 57.73; H, 9.15; N, 7.48; O, 25.63
This product is not in stock, which may be available by custom synthesis.
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Synonym: LAF-153; LAF 153; LAF153;
IUPAC/Chemical Name: (3S,6R)-6-hydroxy-3-(((2S,3R,4S,5R,E)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-en-1-yl)amino)azepan-2-one
InChi Key: JKGVCCOXLJBDCT-RUPMKCBVSA-N
InChi Code: InChI=1S/C18H34N2O6/c1-18(2,3)8-7-13(22)15(23)16(24)14(26-4)10-19-12-6-5-11(21)9-20-17(12)25/h7-8,11-16,19,21-24H,5-6,9-10H2,1-4H3,(H,20,25)/b8-7+/t11-,12+,13-,14+,15+,16+/m1/s1
SMILES Code: O=C1[C@@H](NC[C@H](OC)[C@H](O)[C@@H](O)[C@H](O)/C=C/C(C)(C)C)CC[C@@H](O)CN1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 374.478 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Discovery and Structure-Based Optimization of Next-Generation Reversible Methionine Aminopeptidase-2 (MetAP-2) Inhibitors
Timo Heinrich, Jeyaprakashnarayanan Seenisamy, Beatrix Blume, Jörg Bomke, Michel Calderini, Uwe Eckert, Manja Friese-Hamim, Rainer Kohl, Martin Lehmann, Birgitta Leuthner, Djordje Musil, Felix Rohdich, and Frank T. Zenke
Publication Date (Web): April 2, 2019 (Article)
DOI: 10.1021/acs.jmedchem.9b00041
