DB1255

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565243

CAS#: 915978-94-8 (free base)

Description: DB1255 is a ERG/DNA binding inhibitor which targets the DNA-binding activity of the human ERG transcription factor.


Chemical Structure

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DB1255
CAS# 915978-94-8 (free base)

Theoretical Analysis

MedKoo Cat#: 565243
Name: DB1255
CAS#: 915978-94-8 (free base)
Chemical Formula: C22H18N4S2
Exact Mass: 402.10
Molecular Weight: 402.530
Elemental Analysis: C, 65.64; H, 4.51; N, 13.92; S, 15.93

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 915978-94-8 (free base)   1417897-13-2 (HCl)    

Synonym: DB-1255; DB 1255; DB1255

IUPAC/Chemical Name: 4,4'-([2,2'-Bithiophene]-5,5'-diyl)dibenzimidamide; 4,4'-(2,2'-Bithiene-5,5'-diyl)dibenzenecarboximidamide

InChi Key: RARVJIWPKRBECK-UHFFFAOYSA-N

InChi Code: InChI=1S/C22H18N4S2/c23-21(24)15-5-1-13(2-6-15)17-9-11-19(27-17)20-12-10-18(28-20)14-3-7-16(8-4-14)22(25)26/h1-12H,(H3,23,24)(H3,25,26)

SMILES Code: N=C(N)C1=CC=C(C2=CC=C(C3=CC=C(C4=CC=C(C=C4)C(N)=N)S3)S2)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 402.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Munde M, Kumar A, Peixoto P, Depauw S, Ismail MA, Farahat AA, Paul A, Say MV, David-Cordonnier MH, Boykin DW, Wilson WD. The unusual monomer recognition of guanine-containing mixed sequence DNA by a dithiophene heterocyclic diamidine. Biochemistry. 2014 Feb 25;53(7):1218-27. doi: 10.1021/bi401582t. Epub 2014 Feb 13. PubMed PMID: 24495039; PubMed Central PMCID: PMC3985535.

2: Nhili R, Peixoto P, Depauw S, Flajollet S, Dezitter X, Munde MM, Ismail MA, Kumar A, Farahat AA, Stephens CE, Duterque-Coquillaud M, David Wilson W, Boykin DW, David-Cordonnier MH. Targeting the DNA-binding activity of the human ERG transcription factor using new heterocyclic dithiophene diamidines. Nucleic Acids Res. 2013 Jan 7;41(1):125-38. doi: 10.1093/nar/gks971. Epub 2012 Oct 23. PubMed PMID: 23093599; PubMed Central PMCID: PMC3592449.