ONO-8711 | CAS# 216158-34-8 | EP1 Antagonist

ONO-8711
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WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565228

CAS#: 216158-34-8

Description: ONO-8711 is a selective EP1 antagonist.

Chemical Structure

ONO-8711

CAS# 216158-34-8

Product data Instruction

Theoretical Analysis

MedKoo Cat#: 565228
Name: ONO-8711
CAS#: 216158-34-8
Chemical Formula: C22H30ClNO4S
Exact Mass: 439.16
Molecular Weight: 439.995
Elemental Analysis: C, 60.06; H, 6.87; Cl, 8.06; N, 3.18; O, 14.54; S, 7.29

Price and Availability

Size	Price	Availability	Quantity
5mg	USD 475
10mg	USD 765
25mg	USD 1295
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. MedKoo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: ONO-8711; ONO 8711; ONO8711

IUPAC/Chemical Name: 6-[(2R,3S)-3-[[[(4-Chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-5Z-hexenoic acid

InChi Key: VVEXPDRCGCQELD-CFDZEDGGSA-N

InChi Code: InChI=1S/C22H30ClNO4S/c1-15-13-18(23)11-12-21(15)29(27,28)24-14-20-17-9-7-16(8-10-17)19(20)5-3-2-4-6-22(25)26/h3,5,11-13,16-17,19-20,24H,2,4,6-10,14H2,1H3,(H,25,26)/b5-3-/t16?,17?,19-,20-/m0/s1

SMILES Code: O=C(O)CCC/C=C\[C@H]1C(CC2)CCC2[C@@H]1CNS(=O)(C3=CC=C(Cl)C=C3C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Product Data:

Product Data

Instruction:

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Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 440.00 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:	1. Yang H, Wang M, Sun H, Zhu S, Jin J. Synergetic Effect of EP1 Receptor Antagonist and (-)-Epigallocatechin-3-gallate in Hepatocellular Carcinoma. Pharmacology. 2019;104(5-6):267-275. doi: 10.1159/000502076. Epub 2019 Aug 21. PMID: 31434088. 2. Taub M, Parker R, Mathivanan P, Ariff MA, Rudra T. Antagonism of the prostaglandin E2 EP1 receptor in MDCK cells increases growth through activation of Akt and the epidermal growth factor receptor. Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F539-50. doi: 10.1152/ajprenal.00510.2013. Epub 2014 Jul 9. PMID: 25007872; PMCID: PMC4154115. 3. Wada N, Matsumoto S, Kita M, Watanabe M, Hashizume K, Kakizaki H. Effect of intrathecal administration of E-series prostaglandin 1 receptor antagonist in a cyclophosphamide-induced cystitis rat model. Int J Urol. 2013 Feb;20(2):235-40. doi: 10.1111/j.1442-2042.2012.03126.x. Epub 2012 Aug 26. PMID: 22925406. 4. Takeuchi K, Aihara E, Sasaki Y, Nomura Y, Ise F. Involvement of cyclooxygenase-1, prostaglandin E2 and EP1 receptors in acid-induced HCO3- secretion in stomach. J Physiol Pharmacol. 2006 Dec;57(4):661-76. PMID: 17229989.
In vitro protocol:	1. Yang H, Wang M, Sun H, Zhu S, Jin J. Synergetic Effect of EP1 Receptor Antagonist and (-)-Epigallocatechin-3-gallate in Hepatocellular Carcinoma. Pharmacology. 2019;104(5-6):267-275. doi: 10.1159/000502076. Epub 2019 Aug 21. PMID: 31434088. 2. Taub M, Parker R, Mathivanan P, Ariff MA, Rudra T. Antagonism of the prostaglandin E2 EP1 receptor in MDCK cells increases growth through activation of Akt and the epidermal growth factor receptor. Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F539-50. doi: 10.1152/ajprenal.00510.2013. Epub 2014 Jul 9. PMID: 25007872; PMCID: PMC4154115.
In vivo protocol:	1. Wada N, Matsumoto S, Kita M, Watanabe M, Hashizume K, Kakizaki H. Effect of intrathecal administration of E-series prostaglandin 1 receptor antagonist in a cyclophosphamide-induced cystitis rat model. Int J Urol. 2013 Feb;20(2):235-40. doi: 10.1111/j.1442-2042.2012.03126.x. Epub 2012 Aug 26. PMID: 22925406. 2. Takeuchi K, Aihara E, Sasaki Y, Nomura Y, Ise F. Involvement of cyclooxygenase-1, prostaglandin E2 and EP1 receptors in acid-induced HCO3- secretion in stomach. J Physiol Pharmacol. 2006 Dec;57(4):661-76. PMID: 17229989.

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1: Makita H, Mutoh M, Maruyama T, Yonemoto K, Kobayashi A, Fujitsuka H, Toida M, Shibata T, Miyamoto S, Yasui Y, Suzuki R, Wakabayashi K, Tanaka T. A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Carcinogenesis. 2007 Mar;28(3):677-84. Epub 2006 Oct 19. PubMed PMID: 17052996.

2: Norel X, de Montpreville V, Brink C. Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. Prostaglandins Other Lipid Mediat. 2004 Oct;74(1-4):101-12. PubMed PMID: 15560119.

3: Kawamori T, Uchiya N, Nakatsugi S, Watanabe K, Ohuchida S, Yamamoto H, Maruyama T, Kondo K, Sugimura T, Wakabayashi K. Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development. Carcinogenesis. 2001 Dec;22(12):2001-4. PubMed PMID: 11751431.

4: Kawahara H, Sakamoto A, Takeda S, Onodera H, Imaki J, Ogawa R. A prostaglandin E2 receptor subtype EP1 receptor antagonist (ONO-8711) reduces hyperalgesia, allodynia, and c-fos gene expression in rats with chronic nerve constriction. Anesth Analg. 2001 Oct;93(4):1012-7. PubMed PMID: 11574375.

5: Omote K, Kawamata T, Nakayama Y, Kawamata M, Hazama K, Namiki A. The effects of peripheral administration of a novel selective antagonist for prostaglandin E receptor subtype EP(1), ONO-8711, in a rat model of postoperative pain. Anesth Analg. 2001 Jan;92(1):233-8. PubMed PMID: 11133634.

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