WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565228

CAS#: 216158-34-8

Description: ONO-8711 is a selective EP1 antagonist.

Chemical Structure

CAS# 216158-34-8

Theoretical Analysis

MedKoo Cat#: 565228
Name: ONO-8711
CAS#: 216158-34-8
Chemical Formula: C22H30ClNO4S
Exact Mass: 439.1584
Molecular Weight: 440.0
Elemental Analysis: C, 60.06; H, 6.87; Cl, 8.06; N, 3.18; O, 14.54; S, 7.29

Price and Availability

Size Price Availability Quantity
5.0mg USD 475.0 2 Weeks
10.0mg USD 765.0 2 Weeks
25.0mg USD 1295.0 2 Weeks
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Synonym: ONO-8711; ONO 8711; ONO8711

IUPAC/Chemical Name: 6-[(2R,3S)-3-[[[(4-Chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-5Z-hexenoic acid


InChi Code: InChI=1S/C22H30ClNO4S/c1-15-13-18(23)11-12-21(15)29(27,28)24-14-20-17-9-7-16(8-10-17)19(20)5-3-2-4-6-22(25)26/h3,5,11-13,16-17,19-20,24H,2,4,6-10,14H2,1H3,(H,25,26)/b5-3-/t16?,17?,19-,20-/m0/s1

SMILES Code: O=C(O)CCC/C=C\[C@H]1C(CC2)CCC2[C@@H]1CNS(=O)(C3=CC=C(Cl)C=C3C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 440.0 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Makita H, Mutoh M, Maruyama T, Yonemoto K, Kobayashi A, Fujitsuka H, Toida M, Shibata T, Miyamoto S, Yasui Y, Suzuki R, Wakabayashi K, Tanaka T. A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis. Carcinogenesis. 2007 Mar;28(3):677-84. Epub 2006 Oct 19. PubMed PMID: 17052996.

2: Norel X, de Montpreville V, Brink C. Vasoconstriction induced by activation of EP1 and EP3 receptors in human lung: effects of ONO-AE-248, ONO-DI-004, ONO-8711 or ONO-8713. Prostaglandins Other Lipid Mediat. 2004 Oct;74(1-4):101-12. PubMed PMID: 15560119.

3: Kawamori T, Uchiya N, Nakatsugi S, Watanabe K, Ohuchida S, Yamamoto H, Maruyama T, Kondo K, Sugimura T, Wakabayashi K. Chemopreventive effects of ONO-8711, a selective prostaglandin E receptor EP(1) antagonist, on breast cancer development. Carcinogenesis. 2001 Dec;22(12):2001-4. PubMed PMID: 11751431.

4: Kawahara H, Sakamoto A, Takeda S, Onodera H, Imaki J, Ogawa R. A prostaglandin E2 receptor subtype EP1 receptor antagonist (ONO-8711) reduces hyperalgesia, allodynia, and c-fos gene expression in rats with chronic nerve constriction. Anesth Analg. 2001 Oct;93(4):1012-7. PubMed PMID: 11574375.

5: Omote K, Kawamata T, Nakayama Y, Kawamata M, Hazama K, Namiki A. The effects of peripheral administration of a novel selective antagonist for prostaglandin E receptor subtype EP(1), ONO-8711, in a rat model of postoperative pain. Anesth Analg. 2001 Jan;92(1):233-8. PubMed PMID: 11133634.