WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555510
CAS#: 2216753-86-3 (HCl)
Description: LYN-1604 is a novel activator of ULK1, inducing cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis. LYN-1604 could induce cell death, associated with autophagy by the ULK complex (ULK1-mATG13-FIP200-ATG101) in MDA-MB-231 cells. To further explore LYN-1604-induced autophagic mechanisms, we found some potential ULK1 interactors, such as ATF3, RAD21, and caspase3, by performing comparative microarray analysis. LYN-1604 induced cell death involved in ATF3, RAD21, and caspase3, accompanied by autophagy and apoptosis.
MedKoo Cat#: 555510
Name: LYN-1604 HCl
CAS#: 2216753-86-3 (HCl)
Chemical Formula: C33H44Cl3N3O2
Exact Mass:
Molecular Weight: 621.084
Elemental Analysis: C, 63.82; H, 7.14; Cl, 17.12; N, 6.77; O, 5.15
Related CAS #: 2088939-99-3 (free base) 2216753-86-3 (HCl)
Synonym: LYN-1604 HCl; LYN-1604 hydrochloride; LYN-1604; LYN 1604; LYN1604;
IUPAC/Chemical Name: 2-[bis(2-methylpropyl)amino]-1-[4-[2-(2,4-dichlorophenyl)-2-(2-naphthalenylmethoxy)ethyl]-1-piperazinyl]-ethanone hydrochloride
InChi Key: KWFDUNOLEJSFBQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C33H43Cl2N3O2.ClH/c1-24(2)19-37(20-25(3)4)22-33(39)38-15-13-36(14-16-38)21-32(30-12-11-29(34)18-31(30)35)40-23-26-9-10-27-7-5-6-8-28(27)17-26;/h5-12,17-18,24-25,32H,13-16,19-23H2,1-4H3;1H
SMILES Code: ClC1=CC=C(C(OCC2=CC=C3C=CC=CC3=C2)CN4CCN(C(CN(CC(C)C)CC(C)C)=O)CC4)C(Cl)=C1.Cl
1: Ma S, Yu Z, Feng S, Chen H, Chen H, Lu X. Corneal autophagy and ocular surface
inflammation: A new perspective in dry eye. Exp Eye Res. 2019 Apr 21;184:126-134.
doi: 10.1016/j.exer.2019.04.023. [Epub ahead of print] PubMed PMID: 31018117.
2: Zhang L, Fu L, Zhang S, Zhang J, Zhao Y, Zheng Y, He G, Yang S, Ouyang L, Liu
B. Discovery of a small molecule targeting ULK1-modulated cell death of triple
negative breast cancer in vitro and in vivo. Chem Sci. 2017 Apr 1;8(4):2687-2701.
doi: 10.1039/c6sc05368h. Epub 2017 Jan 9. PubMed PMID: 28553505; PubMed Central
PMCID: PMC5433508.
3: Ouyang L, Zhang L, Fu L, Liu B. A small-molecule activator induces
ULK1-modulating autophagy-associated cell death in triple negative breast cancer.
Autophagy. 2017 Apr 3;13(4):777-778. doi: 10.1080/15548627.2017.1283470. Epub
2017 Feb 6. PubMed PMID: 28165887; PubMed Central PMCID: PMC5388211.