ULK-100

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565181

CAS#: NONE

Description: ULK-100 is a potent ULK1 and ULK2 dual inhibitor.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-30. Prices are subject to change without notice.

ULK-100 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 565181
Name: ULK-100
CAS#: NONE
Chemical Formula: C23H28F3N5O2S
Exact Mass: 495.1916
Molecular Weight: 495.57
Elemental Analysis: C, 55.75; H, 5.70; F, 11.50; N, 14.13; O, 6.46; S, 6.47


Synonym: ULK100; ULK-100; ULK 100

IUPAC/Chemical Name: (S)-4-(6-(2-(Piperidin-1-yl)ethoxy)pyrazolo[1,5-a]pyrimidin-3-yl)-N-(1,1,1-trifluoro-3-methylbutan-2-yl)thiophene-2-carboxamide

InChi Key: IMPQRUJBTLVQMU-FQEVSTJZSA-N

InChi Code: InChI=1S/C23H28F3N5O2S/c1-15(2)20(23(24,25)26)29-22(32)19-10-16(14-34-19)18-12-28-31-13-17(11-27-21(18)31)33-9-8-30-6-4-3-5-7-30/h10-15,20H,3-9H2,1-2H3,(H,29,32)/t20-/m0/s1

SMILES Code: O=C(C1=CC(C2=C3N=CC(OCCN4CCCCC4)=CN3N=C2)=CS1)N[C@@H](C(C)C)C(F)(F)F


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Martin KR, Celano SL, Solitro AR, Gunaydin H, Scott M, O'Hagan RC, Shumway SD, Fuller P, MacKeigan JP. A Potent and Selective ULK1 Inhibitor Suppresses Autophagy and Sensitizes Cancer Cells to Nutrient Stress. iScience. 2018 Oct 26;8:74-84. doi: 10.1016/j.isci.2018.09.012. Epub 2018 Sep 19. PubMed PMID: 30292171; PubMed Central PMCID: PMC6172447.