Ac-Phe-NH2
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 565177

CAS#: 7376-90-1

Description: Ac-Phe-NH2 is a non-competitive inhibitor (Ki = 8 ± 1.2 mM) of polyubiquitin chain elongation by destabilizing the active trimer.


Chemical Structure

img
Ac-Phe-NH2
CAS# 7376-90-1

Theoretical Analysis

MedKoo Cat#: 565177
Name: Ac-Phe-NH2
CAS#: 7376-90-1
Chemical Formula: C11H14N2O2
Exact Mass: 206.11
Molecular Weight: 206.250
Elemental Analysis: C, 64.06; H, 6.84; N, 13.58; O, 15.51

Price and Availability

Size Price Availability Quantity
50mg USD 320 2 Weeks
100mg USD 545 2 Weeks
500mg USD 830 2 Weeks
Bulk inquiry

Synonym: Ac Phe-NH2; Ac-Phe NH2; Ac Phe NH2; Ac-Phe-NH2

IUPAC/Chemical Name: N-Acetylphenylalanyl-amide; (S)-2-Acetamido-3-phenylpropanamide

InChi Key: LRSBEAVFLIKKIO-JTQLQIEISA-N

InChi Code: InChI=1S/C11H14N2O2/c1-8(14)13-10(11(12)15)7-9-5-3-2-4-6-9/h2-6,10H,7H2,1H3,(H2,12,15)(H,13,14)/t10-/m0/s1

SMILES Code: O=C(N)[C@H](CC1=CC=CC=C1)NC(C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 206.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Silver MS, Stoddard M. Kinetic studies on the mechanism of pepsin action. Biochemistry. 1975 Feb 11;14(3):614-21. doi: 10.1021/bi00674a023. PMID: 234250.


2: Meredith D, Temple CS, Guha N, Sword CJ, Boyd CA, Collier ID, Morgan KM, Bailey PD. Modified amino acids and peptides as substrates for the intestinal peptide transporter PepT1. Eur J Biochem. 2000 Jun;267(12):3723-8. doi: 10.1046/j.1432-1327.2000.01405.x. PMID: 10848990.


3: Mitsuta Y, Asada T, Shigeta Y. Calculation of the permeability coefficients of small molecules through lipid bilayers by free-energy reaction network analysis following the explicit treatment of the internal conformation of the solute. Phys Chem Chem Phys. 2022 Nov 2;24(42):26070-26082. doi: 10.1039/d2cp03678a. PMID: 36268802.


4: Loquais Y, Gloaguen E, Alauddin M, Brenner V, Tardivel B, Mons M. On the near UV photophysics of a phenylalanine residue: conformation-dependent ππ* state deactivation revealed by laser spectroscopy of isolated neutral dipeptides. Phys Chem Chem Phys. 2014 Oct 28;16(40):22192-200. doi: 10.1039/c4cp03401e. Epub 2014 Sep 12. PMID: 25213197.


5: DeTar DF. Computation of enzyme-substrate specificity. Biochemistry. 1981 Mar 31;20(7):1730-43. doi: 10.1021/bi00510a005. PMID: 7225355.