WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 565162
Description: A-1165901 is a blocker of the activation of the TRPV1 channel by capsaicin, thereby inducing hypothermia involving tail-skin, vasodilation at thermoneutrality, as well as a decrease body temperature.
MedKoo Cat#: 565162
Chemical Formula: C24H26FN3O3
Exact Mass: 423.1958
Molecular Weight: 423.49
Elemental Analysis: C, 68.07; H, 6.19; F, 4.49; N, 9.92; O, 11.33
This product is not in stock, which may be available by custom synthesis.
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Synonym: A1165901; A-1165901; A 1165901
IUPAC/Chemical Name: 1-((R)-2,2-Diethyl-6-fluoro-chroman-4-yl)-3-(1-methyl-isoquinolon-5-yl)-urea
InChi Key: XRVJVYHEFSIEJG-HXUWFJFHSA-N
InChi Code: InChI=1S/C24H26FN3O3/c1-4-24(5-2)13-20(18-11-15(25)9-10-21(18)31-24)28-23(30)27-19-8-6-7-16-14(3)26-22(29)12-17(16)19/h6-11,20H,4-5,12-13H2,1-3H3,(H2,27,28,30)/t20-/m1/s1
SMILES Code: O=C(NC1=CC=CC2=C1CC(N=C2C)=O)N[C@@H]3CC(CC)(CC)OC4=C3C=C(F)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 423.49 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Garami A, Pakai E, McDonald HA, Reilly RM, Gomtsyan A, Corrigan JJ, Pinter E, Zhu DXD, Lehto SG, Gavva NR, Kym PR, Romanovsky AA. TRPV1 antagonists that cause hypothermia, instead of hyperthermia, in rodents: Compounds' pharmacological profiles, in vivo targets, thermoeffectors recruited and implications for drug development. Acta Physiol (Oxf). 2018 Jul;223(3):e13038. doi: 10.1111/apha.13038. Epub 2018 Feb 16. PubMed PMID: 29352512; PubMed Central PMCID: PMC6032921.