Nafenodone

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MedKoo CAT#: 584885

CAS#: 92615-20-8

Description: Nafenodone is an antidepressant that has effects on rat vascular smooth muscle concentration of intracellular free Ca2+.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-08-09. Prices are subject to change without notice.

Nafenodone is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584885
Name: Nafenodone
CAS#: 92615-20-8
Chemical Formula: C20H23NO
Exact Mass: 293.178
Molecular Weight: 293.41
Elemental Analysis: C, 81.87; H, 7.90; N, 4.77; O, 5.45


Synonym: Nafenodone

IUPAC/Chemical Name: (+-)-2-(2-(Dimethylamino)ethyl)-3,4-dihydro-2-phenyl-1(2H)-naphthalenone

InChi Key: IOKKIRANVRFSAH-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H23NO/c1-21(2)15-14-20(17-9-4-3-5-10-17)13-12-16-8-6-7-11-18(16)19(20)22/h3-11H,12-15H2,1-2H3

SMILES Code: O=C1C(C2=CC=CC=C2)(CCN(C)C)CCC3=C1C=CC=C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Pérez-Vizcaíno F, Carrón R, Delpón E, Duarte J, Tamargo J. Effects of (S)-nafenodone on 45Ca2+ fluxes and contractions in rat isolated vascular smooth muscle. Eur J Pharmacol. 1993 Feb 23;232(1):105-11. PubMed PMID: 8458390.

2: Pérez-Vizcaino F, Carrón R, Delpón E, Tamargo J. Effects of (S)-nafenodone, a new antidepressant, in isolated guinea-pig atrial and ventricular muscle fibres. Eur J Pharmacol. 1991 Jun 18;199(1):43-50. PubMed PMID: 1893926.

3: Delpón E, Valenzuela C, Carrón R, Pérez-Vizcaino F, Tamargo J. Tonic and frequency-dependent Vmax block induced by (S)-nafenodone, a new antidepressant drug, in guinea-pig papillary muscles. Naunyn Schmiedebergs Arch Pharmacol. 1991 Jun;343(6):638-44. PubMed PMID: 1944605.

4: Rao X, Li N, Bai H, Dai C, Wang Z, Tang W. Efficient Synthesis of (-)-Corynoline by Enantioselective Palladium-Catalyzed α-Arylation with Sterically Hindered Substrates. Angew Chem Int Ed Engl. 2018 Sep 17;57(38):12328-12332. doi: 10.1002/anie.201807302. Epub 2018 Aug 28. PubMed PMID: 30074668.

5: Omoigui S, Irene S. Treatment of ptosis as a complication of botulinum toxin injection. Pain Med. 2005 Mar-Apr;6(2):149-51. PubMed PMID: 15773880.

6: Emerich DF, Schneider P, Bintz B, Hudak J, Thanos CG. In vitro exposure of cultured porcine choroid plexus epithelial cells to immunosuppressant, anti-inflammatory, and psychoactive drugs. Cell Transplant. 2007;16(4):435-40. PubMed PMID: 17658133.

7: Jobert M, Jähnig P, Schulz H. Effect of two antidepressant drugs on REM sleep and EMG activity during sleep. Neuropsychobiology. 1999;39(2):101-9. PubMed PMID: 10072667.