WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555502
Description: i472 is a potent 15-LOX-1 inhibitor. In vitro, I472 inhibitor protected cells from lipopolysaccharideinduced cell death, inhibiting NO formation and lipid peroxidation. 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that catalyzes the formation of lipid peroxides. The actions of these peroxides are interconnected with nuclear factor-κB signaling and NO production. Inhibition of 15-LOX-1 holds promise to interfere with regulated cell death in inflammatory conditions.
MedKoo Cat#: 555502
Name: I472 inhibitor
Chemical Formula: C22H21ClN2O4
Exact Mass: 412.119
Molecular Weight: 412.87
Elemental Analysis: C, 64.00; H, 5.13; Cl, 8.59; N, 6.79; O, 15.50
i472 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to firstname.lastname@example.org to inquire quote.
Synonym: i472; i-472; i 472; i472 inhibitor
IUPAC/Chemical Name: Ethyl (E)-6-Chloro-3-(3-((2-methoxybenzyl)amino)-3-oxoprop-1-en-1-yl)-1H-indole-2-carboxylate
InChi Key: BRMZRDPEXXAZRV-ZHACJKMWSA-N
InChi Code: InChI=1S/C22H21ClN2O4/c1-3-29-22(27)21-17(16-9-8-15(23)12-18(16)25-21)10-11-20(26)24-13-14-6-4-5-7-19(14)28-2/h4-12,25H,3,13H2,1-2H3,(H,24,26)/b11-10+
SMILES Code: O=C(C(N1)=C(/C=C/C(NCC2=CC=CC=C2OC)=O)C3=C1C=C(Cl)C=C3)OCC
The following data is based on the product molecular weight 412.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity
Hao Guo, Iris C. Verhoek, Gerian G. H. Prins, Ramon van der Vlag, Petra E. van der Wouden, Ronald van Merkerk, Wim J. Quax, Peter Olinga, Anna K. H. Hirsch, and Frank J. Dekker
Publication Date (Web): April 9, 2019 (Article)