NA 0345

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584880

CAS#: 120925-60-2

Description: NA 0345 is a SF 2370 derivative that produces a selective inhibition of the alpha 1-mediated PIE, probably through inhibition of the alpha 1-adrenoceptor-mediated activation of PKC.


Price and Availability

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NA 0345 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584880
Name: NA 0345
CAS#: 120925-60-2
Chemical Formula: C27H26N4O3
Exact Mass: 454.2005
Molecular Weight: 454.53
Elemental Analysis: C, 71.35; H, 5.77; N, 12.33; O, 10.56


Synonym: NA 0345; NA-0345; NA0345

IUPAC/Chemical Name: 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-10-((methylamino)methyl)-, (9S-(9alpha,10beta,12alpha))-

InChi Key: NCSMUKLSRPWCNB-RJNNFIAUSA-N

InChi Code: InChI=1S/C27H26N4O3/c1-27-9-4-10-30-19-5-3-6-21(32)24(19)23-18-13-29-12-17(18)22-16-8-7-15(34-27)11-20(16)31(27,33,14-28-2)26(22)25(23)30/h4-5,7-9,12-13,15,28,33H,3,6,10-11,14H2,1-2H3/b9-4-/t15-,27+/m1/s1

SMILES Code: O=C(CCC=C12)C1=C3C4=CN=CC4=C5C6=C3N2C/C=C\[C@@](O7)(C)N6(CNC)(O)C8=C5C=C[C@]7([H])C8


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Endoh M, Norota I, Takanashi M, Kasai H. Inotropic effects of staurosporine, NA 0345 and H-7, protein kinase C inhibitors, on rabbit ventricular myocardium: selective inhibition of the positive inotropic effect mediated by alpha 1-adrenoceptors. Jpn J Pharmacol. 1993 Sep;63(1):17-26. PubMed PMID: 8271527.

2: Souhrada M, Souhrada JF. The role of protein kinase-C in sensitization and antigen response of airway smooth muscle. Am Rev Respir Dis. 1989 Dec;140(6):1567-72. PubMed PMID: 2604287.

3: Endoh M. Cardiac alpha(1)-adrenoceptors that regulate contractile function: subtypes and subcellular signal transduction mechanisms. Neurochem Res. 1996 Feb;21(2):217-29. Review. PubMed PMID: 9182246.

4: Okagaki T, Ishikawa R, Kohama K. Inhibitory Ca(2+)-regulation of myosin light chain kinase in the lower eukaryote, Physarum polycephalum: role of a Ca(2+)-dependent inhibitory factor. Eur J Cell Biol. 1991 Oct;56(1):113-22. PubMed PMID: 1666040.

5: Hachisu M, Hiranuma T, Koyama M, Sezaki M. Antihypertensive compounds with potent protein kinases inhibitory activity. Life Sci. 1989;44(19):1351-62. PubMed PMID: 2765030.

6: Souhrada M, Souhrada JF. Inhibitory effect of staurosporine on protein kinase C stimulation of airway smooth muscle cells. Am Rev Respir Dis. 1993 Aug;148(2):425-30. PubMed PMID: 8342907.