AJG-049 HCl

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573515

CAS#: 195991-50-5

Description: AJG-049 HCl is a calcium channel antagonist that inhibits L-type Ca2+ channels via diltiazem-binding site(s).

Chemical Structure

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AJG-049 HCl
CAS# 195991-50-5
Instruction

Theoretical Analysis

MedKoo Cat#: 573515
Name: AJG-049 HCl
CAS#: 195991-50-5
Chemical Formula: C27H31ClN2O2
Exact Mass: 450.21
Molecular Weight: 451.010
Elemental Analysis: C, 71.91; H, 6.93; Cl, 7.86; N, 6.21; O, 7.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AJG-049 HCl, AJG-049 hydrochloride

IUPAC/Chemical Name: 11-(((2R)-1-(2-(4-Methoxyphenyl)ethyl)pyrrolidin-2-yl)methyl)-6H-benzo(C)(1,5)benzoxazepine hydrochloride

InChi Key: QVEPWCHFXPHWJG-GNAFDRTKSA-N

InChi Code: 1S/C27H30N2O2.ClH/c1-30-24-14-12-21(13-15-24)16-18-28-17-6-8-23(28)19-29-25-9-3-2-7-22(25)20-31-27-11-5-4-10-26(27)29;/h2-5,7,9-15,23H,6,8,16-20H2,1H3;1H/t23-;/m1./s1

SMILES Code: Cl.COc1ccc(CCN2CCC[C@@H]2CN3c4ccccc4COc5ccccc35)cc1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 451.01 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zhu HL, Hashimoto M, Teramoto N. Dual action of AJG049, a novel gut selective Ca2+ channel antagonist, on Ba2+ currents and contractions in guinea-pig antrum myocytes. Eur J Pharmacol. 2009 Mar 1;605(1-3):138-44. doi: 10.1016/j.ejphar.2008.12.039. Epub 2009 Jan 10. PubMed PMID: 19168048.

2: Hashimoto M, Teramoto N, Zhu HL, Takahashi K, Ito Y. Comparative studies of AJG049, a novel Ca2+ channel antagonist, on voltage-dependent L-type Ca2+ currents in intestinal and vascular smooth muscle. Br J Pharmacol. 2006 Sep;149(2):155-62. Epub 2006 Aug 14. PubMed PMID: 16921392; PubMed Central PMCID: PMC2013798.