Zacopride hydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573507

CAS#: 99617-34-2

Description: Zacopride hydrochloride is a IK1/Kir2.1 channel agonist which acts as an anti-emetic and peristaltic.


Chemical Structure

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Zacopride hydrochloride
CAS# 99617-34-2

Theoretical Analysis

MedKoo Cat#: 573507
Name: Zacopride hydrochloride
CAS#: 99617-34-2
Chemical Formula: C15H23Cl2N3O3
Exact Mass: 363.1116
Molecular Weight: 364.27
Elemental Analysis: C, 49.46; H, 6.36; Cl, 19.46; N, 11.54; O, 13.18

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: AHR-11190-B, Zacopride hydrochloride, Zacopride HCl

IUPAC/Chemical Name: Benzamide, 4-amino-N-1-azabicyclo(2.2.2)oct-3-yl-5-chloro-2-methoxy-, monohydrochloride, monohydrate

InChi Key: NPXXKMBXEODDAF-UHFFFAOYSA-N

InChi Code: 1S/C15H20ClN3O2.ClH.H2O/c1-21-14-7-12(17)11(16)6-10(14)15(20)18-13-8-19-4-2-9(13)3-5-19;;/h6-7,9,13H,2-5,8,17H2,1H3,(H,18,20);1H;1H2

SMILES Code: O.Cl.COc1cc(N)c(Cl)cc1C(=O)NC2CN3CCC2CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 364.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Zhai XW, Zhang L, Guo YF, Yang Y, Wang DM, Zhang Y, Li P, Niu YF, Feng QL, Wu BW, Cao JM, Liu QH. The IK1/Kir2.1 channel agonist zacopride prevents and cures acute ischemic arrhythmias in the rat. PLoS One. 2017 May 18;12(5):e0177600. doi: 10.1371/journal.pone.0177600. eCollection 2017. PubMed PMID: 28542320; PubMed Central PMCID: PMC5436763.

2: Mele PC, McDonough JR, McLean DB, O'Halloran KP. Cisplatin-induced conditioned taste aversion: attenuation by dexamethasone but not zacopride or GR38032F. Eur J Pharmacol. 1992 Aug 6;218(2-3):229-36. PubMed PMID: 1330594.

3: Sancilio LF, Pinkus LM, Jackson CB, Munson HR Jr. Studies on the emetic and antiemetic properties of zacopride and its enantiomers. Eur J Pharmacol. 1991 Jan 17;192(3):365-9. PubMed PMID: 2055236.