WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555490
CAS#: 2332835-02-4 (free base)
Description: PSB-1901 is a potent A2B Adenosine Receptor Antagonist with Picomolar Potency (Ki 0.0835 nM, KB 0.0598 nM, human A2BAR) with >10 000-fold selectivity versus all other AR subtypes. PSB-1901 was similarly potent and selective at the mouse A2BAR, making it a promising tool for preclinical studies.
MedKoo Cat#: 555490
Name: PSB-1901 free base
CAS#: 2332835-02-4 (free base)
Chemical Formula: C24H25BrN6O4S
Exact Mass: 572.0841
Molecular Weight: 573.466
Elemental Analysis: C, 50.27; H, 4.39; Br, 13.93; N, 14.66; O, 11.16; S, 5.59
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 2332835-02-4 (free base) PSB-1901 HCl
Synonym: PSB-1901; PSB 1901; PSB1901;
IUPAC/Chemical Name: 8-(4-((4-(4-Bromophenyl)piperazin-1-yl)sulfonyl)phenyl)-1-propylxanthine
InChi Key: UGKYSTLSSKLXJO-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H25BrN6O4S/c1-2-11-31-23(32)20-22(28-24(31)33)27-21(26-20)16-3-9-19(10-4-16)36(34,35)30-14-12-29(13-15-30)18-7-5-17(25)6-8-18/h3-10H,2,11-15H2,1H3,(H,26,27)(H,28,33)
SMILES Code: O=C(N1CCC)NC2=C(NC(C3=CC=C(S(=O)(N4CCN(C5=CC=C(Br)C=C5)CC4)=O)C=C3)=N2)C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 573.466 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Jiang J, Seel CJ, Temirak A, Namasivayam V, Arridu A, Schabikowski J, Baqi Y,
Hinz S, Hockemeyer J, Müller CE. A(2B) Adenosine Receptor Antagonists with
Picomolar Potency. J Med Chem. 2019 Apr 15. doi: 10.1021/acs.jmedchem.9b00071.
[Epub ahead of print] PubMed PMID: 30835463.
