Orders received during 11/25~11/29 will be shipped in 11/30/2020 due to Thanksgiving holiday.

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584876

CAS#: 53179-07-0

Description: Nisoxetine is a potent inhibitor for norepinephrine uptake into rat brain synaptosomes and brain.

Price and Availability

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Pricing updated 2020-11-25. Prices are subject to change without notice.

Nisoxetine is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 584876
Name: Nisoxetine
CAS#: 53179-07-0
Chemical Formula: C17H21NO2
Exact Mass: 271.1572
Molecular Weight: 271.36
Elemental Analysis: C, 75.25; H, 7.80; N, 5.16; O, 11.79

Synonym: Nisoxetine

IUPAC/Chemical Name: Benzenepropanamine, gamma-(2-methoxyphenoxy)-N-methyl-


InChi Code: InChI=1S/C17H21NO2/c1-18-13-12-15(14-8-4-3-5-9-14)20-17-11-7-6-10-16(17)19-2/h3-11,15,18H,12-13H2,1-2H3


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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7: Chen YW, Chu CC, Chen YC, Wang JJ, Hung CH, Shao DZ. Nisoxetine produces local but not systemic analgesia against cutaneous nociceptive stimuli in the rat. Eur J Pharmacol. 2012 Jan 30;675(1-3):22-5. doi: 10.1016/j.ejphar.2011.11.042. Epub 2011 Dec 7. PubMed PMID: 22166377.

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14: Gehlert DR, Schober DA, Gackenheimer SL. Comparison of (R)-[3H]tomoxetine and (R/S)-[3H]nisoxetine binding in rat brain. J Neurochem. 1995 Jun;64(6):2792-800. PubMed PMID: 7760060.

15: Shang Y, Dluzen DE. Nisoxetine infusion into the olfactory bulb enhances the capacity for male rats to identify conspecifics. Neuroscience. 2001;104(4):957-64. PubMed PMID: 11457583.

16: Zhen J, Ali S, Dutta AK, Reith ME. Characterization of [³H]CFT binding to the norepinephrine transporter suggests that binding of CFT and nisoxetine is not mutually exclusive. J Neurosci Methods. 2012 Jan 15;203(1):19-27. doi: 10.1016/j.jneumeth.2011.08.044. Epub 2011 Sep 12. PubMed PMID: 21933682; PubMed Central PMCID: PMC3221803.

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