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MedKoo CAT#: 555484
CAS#: 2244904-70-7
Description: BAY-293 is a potent SOS1 inhibitor that blocks RAS activation via disruption of the RAS-SOS1 interaction. BAY-293) selectively inhibits the KRAS-SOS1 interaction with an IC50 of 21 nM and is a valuable chemical probe for future investigations.
MedKoo Cat#: 555484
Name: BAY-293
CAS#: 2244904-70-7
Chemical Formula: C25H28N4O2S
Exact Mass: 448.1933
Molecular Weight: 448.585
Elemental Analysis: C, 66.94; H, 6.29; N, 12.49; O, 7.13; S, 7.15
Related CAS #: 2244904-70-7 2244904-69-4 (S-isomer) 2244904-14 (racemic)
Synonym: BAY-293; BAY 293; BAY293;
IUPAC/Chemical Name: (R)-6,7-dimethoxy-2-methyl-N-(1-(4-(2-((methylamino)methyl)phenyl)thiophen-2-yl)ethyl)quinazolin-4-amine
InChi Key: WEGLOYDTDILXDA-OAHLLOKOSA-N
InChi Code: InChI=1S/C25H28N4O2S/c1-15(24-10-18(14-32-24)19-9-7-6-8-17(19)13-26-3)27-25-20-11-22(30-4)23(31-5)12-21(20)28-16(2)29-25/h6-12,14-15,26H,13H2,1-5H3,(H,27,28,29)/t15-/m1/s1
SMILES Code: C[C@@H](NC1=C2C=C(OC)C(OC)=CC2=NC(C)=N1)C3=CC(C4=CC=CC=C4CNC)=CS3
1: Hillig RC, Sautier B, Schroeder J, Moosmayer D, Hilpmann A, Stegmann CM,
Werbeck ND, Briem H, Boemer U, Weiske J, Badock V, Mastouri J, Petersen K,
Siemeister G, Kahmann JD, Wegener D, Böhnke N, Eis K, Graham K, Wortmann L, von
Nussbaum F, Bader B. Discovery of potent SOS1 inhibitors that block RAS
activation via disruption of the RAS-SOS1 interaction. Proc Natl Acad Sci U S A.
2019 Feb 12;116(7):2551-2560. doi: 10.1073/pnas.1812963116. Epub 2019 Jan 25.
PubMed PMID: 30683722; PubMed Central PMCID: PMC6377443.