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MedKoo CAT#: 584874

CAS#: 24751-69-7

Description: Nulceocidin is an antibiotic and fluorine-containing nucleoside produced by Streptomyces calvus.

Price and Availability

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Pricing updated 2020-09-22. Prices are subject to change without notice.

Nulceocidin is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 584874
Name: Nulceocidin
CAS#: 24751-69-7
Chemical Formula: C10H13FN6O6S
Exact Mass: 364.0601
Molecular Weight: 364.3084
Elemental Analysis: C, 32.97; H, 3.60; F, 5.21; N, 23.07; O, 26.35; S, 8.80

Synonym: Nulceocidin; Antibiotic T-3018; T-3018

IUPAC/Chemical Name: Adenosine, 4'-C-fluoro-, 5'-sulfamate


InChi Code: InChI=1S/C10H13FN6O6S/c11-10(1-22-24(13,20)21)6(19)5(18)9(23-10)17-3-16-4-7(12)14-2-15-8(4)17/h2-3,5-6,9,18-19H,1H2,(H2,12,14,15)(H2,13,20,21)/t5-,6+,9-,10-/m1/s1

SMILES Code: O[C@@H]([C@H]([C@H](N1C=NC2=C(N=CN=C21)N)O3)O)[C@@]3(F)COS(=O)(N)=O

Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


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2: Feng X, Al Maharik N, Bartholomé A, Janso JE, Reilly U, O'Hagan D. Incorporation of [(2)H(1)]-(1R,2R)- and [(2)H(1)]-(1S,2R)-glycerols into the antibiotic nucleocidin in Streptomyces calvus. Org Biomol Chem. 2017 Oct 4;15(38):8006-8008. doi: 10.1039/c7ob02163a. PubMed PMID: 28920128.

3: Bartholomé A, Janso JE, Reilly U, O'Hagan D. Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus. Org Biomol Chem. 2016 Dec 20;15(1):61-64. PubMed PMID: 27845468.

4: Carvalho MF, Oliveira RS. Natural production of fluorinated compounds and biotechnological prospects of the fluorinase enzyme. Crit Rev Biotechnol. 2017 Nov;37(7):880-897. doi: 10.1080/07388551.2016.1267109. Epub 2017 Jan 3. Review. PubMed PMID: 28049355.

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6: Florini JR, Bird HH, Bell PH. Inhibition of protein synthesis in vitro and in vivo by nucleocidin, an antitrypanosomal antibiotic. J Biol Chem. 1966 Mar 10;241(5):1091-8. PubMed PMID: 5933868.

7: Williamson J, Macadam RF. Drug effects on the fine structure of Trypanosoma rhodesiense: puromycin and its aminonucleoside, Cordycepin and Nucleocidin. Trans R Soc Trop Med Hyg. 1976;70(2):130-7. PubMed PMID: 1085509.

8: BACKUS EJ, TRESNER HD, CAMPBELL TH. The nucleocidin and alazopetin producing organisms: two new species of Streptomyces. Antibiot Chemother (Northfield). 1957 Oct;7(10):532-41. PubMed PMID: 24544578.

9: THOMAS SO, SINGLETON VL, LOWERY JA, SHARPE RW, PRUESS LM, PORTER JN, MOWAT JH, BOHONOS N. Nucleocidin, a new antibiotic with activity against Trypanosomes. Antibiot Annu. 1956-1957:716-21. PubMed PMID: 13425454.

10: HEWITT RI, GUMBLE AR, TAYLOR LH, WALLACE WS. The activity of a new antibiotic, nucleocidin, in experimental infections with Trypanosoma equiperdum. Antibiot Annu. 1956-1957:722-9. PubMed PMID: 13425455.

11: Zhang S, Klementz D, Zhu J, Makitrynskyy R, Ola Pasternak AR, Günther S, Zechel DL, Bechthold A. Genome mining reveals the origin of a bald phenotype and a cryptic nucleocidin gene cluster in Streptomyces asterosporus DSM 41452. J Biotechnol. 2019 Feb 20;292:23-31. doi: 10.1016/j.jbiotec.2018.12.016. Epub 2019 Jan 11. PubMed PMID: 30641108.

12: Jenkins ID, Verheyden JP, Moffatt JG. Synthesis of the nucleoside antibiotic nucleocidin. J Am Chem Soc. 1971 Aug 25;93(17):4323-4. PubMed PMID: 5131149.

13: TOBIE EJ. The trypanocidal effect of nucleocidin in vivo. J Parasitol. 1957 Jun;43(3):291-3. PubMed PMID: 13439466.

14: STEPHEN LE, GRAY AR. The trypanocidal activity of nucleocidin against Trypanosoma vivax in West African zebu cattle. J Parasitol. 1960 Aug;46:509-14. PubMed PMID: 13834368.

15: Shuman D, Robbins RK, Robins MJ. The synthesis of adenine 5'-O-sulfamoyl nucleosides related to nucleocidin. J Am Chem Soc. 1969 Jun 4;91(12):3391-2. PubMed PMID: 5791926.

16: Shuman DA, Robins MJ, Robins RK. The synthesis of nucleos9de sulfamates related to nucleocidin. J Am Chem Soc. 1970 Jun 3;92(11):3434-40. PubMed PMID: 5422764.

17: Jaffe JJ, McCormack JJ, Meymerian E. Trypanocidal properties of 5'-O-Sulfamoyladenosine, a close structural analog of nucleocidin. Exp Parasitol. 1970 Dec;28(3):535-43. PubMed PMID: 5499671.

18: Jenkins ID, Verheyden JP, Moffatt JG. 4'-Substituted nucleosides. 2. Synthesis of the nucleoside antibiotic nucleocidin. J Am Chem Soc. 1976 May 26;98(11):3346-57. PubMed PMID: 1262649.

19: Kalan L, Gessner A, Thaker MN, Waglechner N, Zhu X, Szawiola A, Bechthold A, Wright GD, Zechel DL. A cryptic polyene biosynthetic gene cluster in Streptomyces calvus is expressed upon complementation with a functional bldA gene. Chem Biol. 2013 Oct 24;20(10):1214-24. doi: 10.1016/j.chembiol.2013.09.006. Epub 2013 Oct 10. PubMed PMID: 24120331.

20: Bacchi J, Lambros C, Goldberg B, Hutner SH, de Carvalho GD. Susceptibility of an insect Leptomonas and Crithidia fasciculata to several established antitrypanosomatid agents. Antimicrob Agents Chemother. 1974 Dec;6(6):785-90. PubMed PMID: 4451351; PubMed Central PMCID: PMC444737.