AGN-191659

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573477

CAS#: 156691-86-0

Description: AGN-191659 is a Retinoid X Receptor (RXR) pan-agonist. RXR pan-agonists have been shown to modulate endothelial cell proliferation.

Chemical Structure

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AGN-191659
CAS# 156691-86-0
Instruction

Theoretical Analysis

MedKoo Cat#: 573477
Name: AGN-191659
CAS#: 156691-86-0
Chemical Formula: C23H28O2S
Exact Mass: 368.18
Molecular Weight: 368.540
Elemental Analysis: C, 74.96; H, 7.66; O, 8.68; S, 8.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: AGN-191659, AGN191659, AGN 191659

IUPAC/Chemical Name: (E)-5-(2-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)propen-1-yl)-2-thiophenecarboxylic acid

InChi Key: QPAMXNZWXFZISY-SDNWHVSQSA-N

InChi Code: 1S/C23H28O2S/c1-14(11-16-7-8-20(26-16)21(24)25)17-13-19-18(12-15(17)2)22(3,4)9-10-23(19,5)6/h7-8,11-13H,9-10H2,1-6H3,(H,24,25)/b14-11+

SMILES Code: c1(ccc(s1)\C=C(/C)c1cc2C(CCC(c2cc1C)(C)C)(C)C)C(=O)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 368.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Standeven AM, Thacher SM, Yuan YD, Escobar M, Vuligonda V, Beard RL, Chandraratna RA. Retinoid X receptor agonist elevation of serum triglycerides in rats by potentiation of retinoic acid receptor agonist induction or by action as single agents. Biochem Pharmacol. 2001 Dec 1;62(11):1501-9. PubMed PMID: 11728386.

2: Pakala R, Benedict CR. Modulation of endothelial cell proliferation by retinoid x receptor agonists. Eur J Pharmacol. 1999 Dec 3;385(2-3):255-61. PubMed PMID: 10607884.