Lansoprazole sulfide
featured

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573458

CAS#: 103577-40-8

Description: Lansoprazole sulfide is an impurity of Lansoprazole -- a gastric pump inhibitor.


Chemical Structure

img
Lansoprazole sulfide
CAS# 103577-40-8

Theoretical Analysis

MedKoo Cat#: 573458
Name: Lansoprazole sulfide
CAS#: 103577-40-8
Chemical Formula: C16H14F3N3OS
Exact Mass: 353.081
Molecular Weight: 353.36
Elemental Analysis: C, 54.38; H, 3.99; F, 16.13; N, 11.89; O, 4.53; S, 9.07

Price and Availability

Size Price Availability Quantity
1.0g USD 330.0 2 Weeks
5.0g USD 900.0 2 Weeks
Bulk inquiry

Synonym: AG-1777, EC 600-451-9, H 225/18, K-1252, Lansoprazole impurity C , Lansoprazole sulfide

IUPAC/Chemical Name: 1H-Benzimidazole, 2-(((3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl)methyl)thio)-

InChi Key: CCHLMSUZHFPSFC-UHFFFAOYSA-N

InChi Code: 1S/C16H14F3N3OS/c1-10-13(20-7-6-14(10)23-9-16(17,18)19)8-24-15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)

SMILES Code: Cc1c(ccnc1CSc2[nH]c3ccccc3n2)OCC(F)(F)F

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 353.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Mdanda S, Baijnath S, Shobo A, Singh SD, Maguire GEM, Kruger HG, Arvidsson PI, Naicker T, Govender T. Lansoprazole-sulfide, pharmacokinetics of this promising anti-tuberculous agent. Biomed Chromatogr. 2017 Dec;31(12). doi: 10.1002/bmc.4035. Epub 2017 Jul 13. PubMed PMID: 28623874.

2: Rybniker J, Vocat A, Sala C, Busso P, Pojer F, Benjak A, Cole ST. Lansoprazole is an antituberculous prodrug targeting cytochrome bc1. Nat Commun. 2015 Jul 9;6:7659. doi: 10.1038/ncomms8659. PubMed PMID: 26158909; PubMed Central PMCID: PMC4510652.

3: Pearce RE, Rodrigues AD, Goldstein JA, Parkinson A. Identification of the human P450 enzymes involved in lansoprazole metabolism. J Pharmacol Exp Ther. 1996 May;277(2):805-16. PubMed PMID: 8627562.

4: Landes BD, Petite JP, Flouvat B. Clinical pharmacokinetics of lansoprazole. Clin Pharmacokinet. 1995 Jun;28(6):458-70. Review. PubMed PMID: 7656504.