WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555468
CAS#: 334951-90-5
Description: BIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI). X-ray structure analysis showed that BIBF0775 soaked into the kinase domain of TGFβRI.
MedKoo Cat#: 555468
Name: BIBF0775
CAS#: 334951-90-5
Chemical Formula: C31H34N4O2
Exact Mass: 494.2682
Molecular Weight: 494.639
Elemental Analysis: C, 75.28; H, 6.93; N, 11.33; O, 6.47
Synonym: BIBF0775; BIBF-0775; BIBF 0775;
IUPAC/Chemical Name: (3Z)-N-Ethyl-2,3-dihydro-N-methyl-2-oxo-3-[phenyl[[4-(1-piperidinylmethyl)phenyl]amino]methylene]-1H-indole-6-carboxamide
InChi Key: MUSRTIADFPCYTQ-ZIADKAODSA-N
InChi Code: InChI=1S/C31H34N4O2/c1-3-34(2)31(37)24-14-17-26-27(20-24)33-30(36)28(26)29(23-10-6-4-7-11-23)32-25-15-12-22(13-16-25)21-35-18-8-5-9-19-35/h4,6-7,10-17,20,32H,3,5,8-9,18-19,21H2,1-2H3,(H,33,36)/b29-28-
SMILES Code: O=C(C1=CC(NC/2=O)=C(C=C1)C2=C(C3=CC=CC=C3)\NC4=CC=C(CN5CCCCC5)C=C4)N(CC)C
Inhibition of transforming growth factor β (TGFβ) type I receptor (Alk5) offers a novel approach for the treatment of fibrotic diseases and cancer.
1: Roth GJ, Heckel A, Brandl T, Grauert M, Hoerer S, Kley JT, Schnapp G, Baum P,
Mennerich D, Schnapp A, Park JE. Design, synthesis, and evaluation of indolinones
as inhibitors of the transforming growth factor β receptor I (TGFβRI). J Med
Chem. 2010 Oct 28;53(20):7287-95. doi: 10.1021/jm100812a. PubMed PMID: 20919678.