Nesolicaftor
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555467

CAS#: 1953130-87-4

Description: Nesolicaftor, also known as PTI-428, is a type of CFTR modulator known as an amplifier, which acts to increase the amount of CFTR proteins a cell makes.


Price and Availability

Size Price Shipping out time Quantity
50mg USD 1050 2 Weeks
100mg USD 1650 2 Weeks
200mg USD 2450 2 Weeks
500mg USD 3750 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-30. Prices are subject to change without notice.

Nesolicaftor, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 555467
Name: Nesolicaftor
CAS#: 1953130-87-4
Chemical Formula: C18H18N4O4
Exact Mass: 354.1328
Molecular Weight: 354.366
Elemental Analysis: C, 61.01; H, 5.12; N, 15.81; O, 18.06


Related CAS #: 1953130-87-4  

Synonym: PTI-428; PTI 428; PTI428; Nesolicaftor;

IUPAC/Chemical Name: N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide

InChi Key: XPEHHUISIBFLHX-RAIGVLPGSA-N

InChi Code: InChI=1S/C18H18N4O4/c1-10(23)17-20-21-18(25-17)12-7-13(8-12)19-16(24)15-9-14(22-26-15)11-5-3-2-4-6-11/h2-6,9-10,12-13,23H,7-8H2,1H3,(H,19,24)/t10-,12-,13-/m1/s1

SMILES Code: O=C(C1=CC(C2=CC=CC=C2)=NO1)N[C@H]3C[C@H](C4=NN=C([C@H](O)C)O4)C3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

There are two other types of CFTR modulators: potentiators, such as Kalydeco (ivacaftor), which help chloride ions flow through the CFTR channel; and correctors, such as lumacaftor and tezacaftor, which help mutated CFTR proteins form the right shape to allow sufficient water and salt transport across cell membranes.