WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555467
Description: Nesolicaftor, also known as PTI-428, is a type of CFTR modulator known as an amplifier, which acts to increase the amount of CFTR proteins a cell makes.
MedKoo Cat#: 555467
Chemical Formula: C18H18N4O4
Exact Mass: 354.1328
Molecular Weight: 354.366
Elemental Analysis: C, 61.01; H, 5.12; N, 15.81; O, 18.06
Related CAS #: 1953130-87-4
Synonym: PTI-428; PTI 428; PTI428; Nesolicaftor;
IUPAC/Chemical Name: N-(trans-3-[5-[(1R)-1-hydroxyethyl]-1,3,4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1,2-oxazole-5-carboxamide
InChi Key: XPEHHUISIBFLHX-RAIGVLPGSA-N
InChi Code: InChI=1S/C18H18N4O4/c1-10(23)17-20-21-18(25-17)12-7-13(8-12)19-16(24)15-9-14(22-26-15)11-5-3-2-4-6-11/h2-6,9-10,12-13,23H,7-8H2,1H3,(H,19,24)/t10-,12-,13-/m1/s1
SMILES Code: O=C(C1=CC(C2=CC=CC=C2)=NO1)N[C@H]3C[C@H](C4=NN=C([C@H](O)C)O4)C3
There are two other types of CFTR modulators: potentiators, such as Kalydeco (ivacaftor), which help chloride ions flow through the CFTR channel; and correctors, such as lumacaftor and tezacaftor, which help mutated CFTR proteins form the right shape to allow sufficient water and salt transport across cell membranes.