WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573445
CAS#: 189638-30-0 (HCl)
Description: Fabomotizole dihydrochloride is an σ1 receptor agonist with cardioprotective and anxiolytic properties.
MedKoo Cat#: 573445
Name: Fabomotizole dihydrochloride
CAS#: 189638-30-0 (HCl)
Chemical Formula: C15H23Cl2N3O2S
Exact Mass: 379.0888
Molecular Weight: 380.33
Elemental Analysis: C, 47.37; H, 6.10; Cl, 18.64; N, 11.05; O, 8.41; S, 8.43
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Synonym: Afobazol dihydrochloride, Fabomotizole dihydrochloride;
IUPAC/Chemical Name: 1H-Benzimidazole, 6-ethoxy-2-((2-(4-morpholinyl)ethyl)thio)-, hydrochloride (1:2)
InChi Key: OFMVMQZFMVQDFO-UHFFFAOYSA-N
InChi Code: 1S/C15H21N3O2S.2ClH/c1-2-20-12-3-4-13-14(11-12)17-15(16-13)21-10-7-18-5-8-19-9-6-18;;/h3-4,11H,2,5-10H2,1H3,(H,16,17);2*1H
SMILES Code: CCOc1ccc2c(c1)[nH]c(n2)SCCN3CCOCC3.Cl.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 380.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Kryzhanovskii SA, Kozhevnikova LM, Tsorin IB, Sukhanova IF, Ionova EO, Stolyaruk VN, Vititnova MB, Miroshkina IA, Seredenin SB. On the Mechanism of the Cardioprotective Action of σ(1) Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole). Bull Exp Biol Med. 2018 Sep;165(5):660-664. doi: 10.1007/s10517-018-4236-1. Epub 2018 Sep 17. PubMed PMID: 30225699.
2: Kolik LG, Nadorova AV, Stolyaruk VN, Miroshkina IA, Tsorin IB, Kryzhanovskii SA. Anxiolytic Properties of Trimetazidine in Experimental Models of Increased Anxiety. Bull Exp Biol Med. 2017 Mar;162(5):643-646. doi: 10.1007/s10517-017-3677-2. Epub 2017 Mar 31. PubMed PMID: 28361425.
3: Syunyakov TS, Neznamov GG. [Evaluation of the therapeutic efficacy and safety of the selective anxiolytic afobazole in generalized anxiety disorder and adjustment disorders: Results of a multicenter randomized comparative study of diazepam]. Ter Arkh. 2016;88(8):73-86. doi: 10.17116/terarkh201688873-86. Russian. PubMed PMID: 27636931.