Fabomotizole dihydrochloride

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573445

CAS#: 189638-30-0 (HCl)

Description: Fabomotizole dihydrochloride is an σ1 receptor agonist with cardioprotective and anxiolytic properties.


Chemical Structure

img
Fabomotizole dihydrochloride
CAS# 189638-30-0 (HCl)

Theoretical Analysis

MedKoo Cat#: 573445
Name: Fabomotizole dihydrochloride
CAS#: 189638-30-0 (HCl)
Chemical Formula: C15H23Cl2N3O2S
Exact Mass: 379.0888
Molecular Weight: 380.33
Elemental Analysis: C, 47.37; H, 6.10; Cl, 18.64; N, 11.05; O, 8.41; S, 8.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 173352-21-1 (free base)   189638-30-0 (HCl)    

Synonym: Afobazol dihydrochloride, Fabomotizole dihydrochloride;

IUPAC/Chemical Name: 1H-Benzimidazole, 6-ethoxy-2-((2-(4-morpholinyl)ethyl)thio)-, hydrochloride (1:2)

InChi Key: OFMVMQZFMVQDFO-UHFFFAOYSA-N

InChi Code: 1S/C15H21N3O2S.2ClH/c1-2-20-12-3-4-13-14(11-12)17-15(16-13)21-10-7-18-5-8-19-9-6-18;;/h3-4,11H,2,5-10H2,1H3,(H,16,17);2*1H

SMILES Code: CCOc1ccc2c(c1)[nH]c(n2)SCCN3CCOCC3.Cl.Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 380.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Kryzhanovskii SA, Kozhevnikova LM, Tsorin IB, Sukhanova IF, Ionova EO, Stolyaruk VN, Vititnova MB, Miroshkina IA, Seredenin SB. On the Mechanism of the Cardioprotective Action of σ(1) Receptor Agonist Anxiolytic Fabomotizole Hydrochloride (Afobazole). Bull Exp Biol Med. 2018 Sep;165(5):660-664. doi: 10.1007/s10517-018-4236-1. Epub 2018 Sep 17. PubMed PMID: 30225699.

2: Kolik LG, Nadorova AV, Stolyaruk VN, Miroshkina IA, Tsorin IB, Kryzhanovskii SA. Anxiolytic Properties of Trimetazidine in Experimental Models of Increased Anxiety. Bull Exp Biol Med. 2017 Mar;162(5):643-646. doi: 10.1007/s10517-017-3677-2. Epub 2017 Mar 31. PubMed PMID: 28361425.

3: Syunyakov TS, Neznamov GG. [Evaluation of the therapeutic efficacy and safety of the selective anxiolytic afobazole in generalized anxiety disorder and adjustment disorders: Results of a multicenter randomized comparative study of diazepam]. Ter Arkh. 2016;88(8):73-86. doi: 10.17116/terarkh201688873-86. Russian. PubMed PMID: 27636931.