WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 573443
CAS#: 121029-35-4
Description: Otenzepad, (+)- is a muscarinic receptor antagonist.
MedKoo Cat#: 573443
Name: Otenzepad, (+)-
CAS#: 121029-35-4
Chemical Formula: C24H31N5O2
Exact Mass: 421.2478
Molecular Weight: 421.55
Elemental Analysis: C, 68.38; H, 7.41; N, 16.61; O, 7.59
This product is not in stock, which may be available by custom synthesis.
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Synonym: AF-DX-250, AFDX-250, Otenzepad, (+)-
IUPAC/Chemical Name: 6H-Pyrido(2,3-b)(1,4)benzodiazepin-6-one, 11-(2-(2-((diethylamino)methyl)-1-piperidinyl)acetyl)-5,11-dihydro-, (+)-
InChi Key: UBRKDAVQCKZSPO-UHFFFAOYSA-N
InChi Code: 1S/C24H31N5O2/c1-3-27(4-2)16-18-10-7-8-15-28(18)17-22(30)29-21-13-6-5-11-19(21)24(31)26-20-12-9-14-25-23(20)29/h5-6,9,11-14,18H,3-4,7-8,10,15-17H2,1-2H3,(H,26,31)
SMILES Code: CCN(CC)CC1CCCCN1CC(=O)N2c3ccccc3C(=O)Nc4cccnc24
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 421.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
1: Leaderbrand K, Chen HJ, Corcoran KA, Guedea AL, Jovasevic V, Wess J, Radulovic J. Muscarinic acetylcholine receptors act in synergy to facilitate learning and memory. Learn Mem. 2016 Oct 17;23(11):631-638. doi: 10.1101/lm.043133.116. Print 2016 Nov. PubMed PMID: 27918283; PubMed Central PMCID: PMC5066603.
2: Lanzafame A, Christopoulos A, Mitchelson F. The allosteric interaction of otenzepad (AF-DX 116) at muscarinic M2 receptors in guinea pig atria. Eur J Pharmacol. 2001 Mar 30;416(3):235-44. Erratum in: Eur J Pharmacol 2001 Jun 29;423(1):93-4. PubMed PMID: 11290374.
3: Bellido I, Fernández JL, Gómez A, Sánchez de la Cuesta F. Otenzepad shows two populations of binding sites in human gastric smooth muscle. Can J Physiol Pharmacol. 1995 Jan;73(1):124-9. PubMed PMID: 7600442.
