Negletein
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MedKoo CAT#: 584843

CAS#: 29550-13-8

Description: Negletein is a neuroprotectant.


Price and Availability

Size Price Shipping out time Quantity
5mg USD 225 2 Weeks
10mg USD 350 2 Weeks
50mg USD 580 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-09-28. Prices are subject to change without notice.

Negletein, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 584843
Name: Negletein
CAS#: 29550-13-8
Chemical Formula: C16H12O5
Exact Mass: 284.0685
Molecular Weight: 284.267
Elemental Analysis: C, 67.60; H, 4.26; O, 28.14


Synonym: Negletein

IUPAC/Chemical Name: 4H-1-Benzopyran-4-one, 5,6-dihydroxy-7-methoxy-2-phenyl-

InChi Key: ZTHLHHDJRXJGRX-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H12O5/c1-20-13-8-12-14(16(19)15(13)18)10(17)7-11(21-12)9-5-3-2-4-6-9/h2-8,18-19H,1H3

SMILES Code: O=C1C=C(C2=CC=CC=C2)OC3=CC(OC)=C(O)C(O)=C13


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Phan CW, Sabaratnam V, Bovicelli P, Righi G, Saso L. Negletein as a neuroprotectant enhances the action of nerve growth factor and induces neurite outgrowth in PC12 cells. Biofactors. 2016 Nov 12;42(6):591-599. doi: 10.1002/biof.1296. Epub 2016 May 19. PubMed PMID: 27193378.

2: Wu J, Chen Y, Liu X, Gao Y, Hu J, Chen H. Discovery of novel negletein derivatives as potent anticancer agents for acute myeloid leukemia. Chem Biol Drug Des. 2018 Apr;91(4):924-932. doi: 10.1111/cbdd.13159. Epub 2018 Jan 17. PubMed PMID: 29240303.

3: Havermann S, Chovolou Y, Humpf HU, Wätjen W. Modulation of the Nrf2 signalling pathway in Hct116 colon carcinoma cells by baicalein and its methylated derivative negletein. Pharm Biol. 2016 Sep;54(9):1491-502. doi: 10.3109/13880209.2015.1104703. Epub 2016 May 4. PubMed PMID: 27143122.

4: Banerjee P, Sahoo A, Anand S, Ganguly A, Righi G, Bovicelli P, Saso L, Chakrabarti S. Multiple mechanisms of iron-induced amyloid beta-peptide accumulation in SHSY5Y cells: protective action of negletein. Neuromolecular Med. 2014 Dec;16(4):787-98. doi: 10.1007/s12017-014-8328-4. Epub 2014 Sep 24. PubMed PMID: 25249289.

5: Nakajima A, Yamamoto Y, Yoshinaka N, Namba M, Matsuo H, Okuyama T, Yoshigai E, Okumura T, Nishizawa M, Ikeya Y. A new flavanone and other flavonoids from green perilla leaf extract inhibit nitric oxide production in interleukin 1β-treated hepatocytes. Biosci Biotechnol Biochem. 2015;79(1):138-46. doi: 10.1080/09168451.2014.962474. Epub 2014 Sep 30. PubMed PMID: 25266050.

6: Lombardo E, Sabellico C, Hájek J, Staňková V, Filipský T, Balducci V, De Vito P, Leone S, Bavavea EI, Silvestri IP, Righi G, Luly P, Saso L, Bovicelli P, Pedersen JZ, Incerpi S. Protection of cells against oxidative stress by nanomolar levels of hydroxyflavones indicates a new type of intracellular antioxidant mechanism. PLoS One. 2013 Apr 18;8(4):e60796. doi: 10.1371/journal.pone.0060796. Print 2013. PubMed PMID: 23637768; PubMed Central PMCID: PMC3630532.

7: Singh B, Jain SK, Bharate SB, Kushwaha M, Gupta AP, Vishwakarma RA. Simultaneous Quantification of Five Bioactive Flavonoids in High Altitude Plant Actinocarya tibetica by LC-ESI-MS/MS. J AOAC Int. 2015 Jul-Aug;98(4):907-12. doi: 10.5740/jaoacint.14-270. PubMed PMID: 26268971.

8: Rajendran N, Subramaniam S, Christena LR, Muthuraman MS, Subramanian NS, Pemiah B, Sivasubramanian A. Antimicrobial flavonoids isolated from Indian medicinal plant Scutellaria oblonga inhibit biofilms formed by common food pathogens. Nat Prod Res. 2016 Sep;30(17):2002-6. doi: 10.1080/14786419.2015.1104673. Epub 2015 Oct 28. PubMed PMID: 26508034.

9: Kiem PV, Minh CV, Huong HT, Lee JJ, Lee IS, Kim YH. Phenolic constituents with inhibitory activity against NFAT transcription from Desmos chinensis. Arch Pharm Res. 2005 Dec;28(12):1345-9. PubMed PMID: 16392667.

10: Jing LL, He L, Fan PC, Jia ZP, Ma HP. [Chemical Constituents with Anti-hypoxia Activity from Saussurea involucrata]. Zhong Yao Cai. 2015 Jan;38(1):89-92. Chinese. PubMed PMID: 26214875.

11: Singh B, Sidiq T, Joshi P, Jain SK, Lawaniya Y, Kichlu S, Khajuria A, Vishwakarma RA, Bharate SB. Anti-inflammatory and immunomodulatory flavones from Actinocarya tibetica Benth. Nat Prod Res. 2013;27(23):2227-30. doi: 10.1080/14786419.2013.805334. Epub 2013 Jun 14. PubMed PMID: 23768253.

12: Zhang NL, Liu X, Shen XC, Cai JZ, Hu YJ, Qiu SX. [Chemical Constituents from Periploca forrestii]. Zhong Yao Cai. 2016 Feb;39(2):329-30. Chinese. PubMed PMID: 30080369.

13: Chen L, Wang Q, Tang Y. Study of degradation behavior of baicalin during simulative blood sample processing with solid phase extraction technology and identification of the degradation product. Drug Metab Lett. 2011 Dec;5(4):276-9. PubMed PMID: 22292474.

14: Hu HW, Xie XM, Zhang PZ, Shu RG. [Study on the flavonoids from Mosla chinensis 'jiangxiangru']. Zhong Yao Cai. 2010 Feb;33(2):218-9. Chinese. PubMed PMID: 20575414.