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MedKoo CAT#: 564991

CAS#: 325165-07-9

Description: NVP-QAB205 is a Syk inhibitor.

Price and Availability

Size Price Shipping out time Quantity
Inquire bulk and customized quantity

Pricing updated 2020-09-26. Prices are subject to change without notice.

NVP-QAB205 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.

Chemical Structure


Theoretical Analysis

MedKoo Cat#: 564991
Name: NVP-QAB205
CAS#: 325165-07-9
Chemical Formula: C18H22ClN7O
Exact Mass:
Molecular Weight: 387.87
Elemental Analysis: C, 55.74; H, 5.72; Cl, 9.14; N, 25.28; O, 4.12

Synonym: NVPQAB205; NVP QAB205; NVP-QAB205; QAB205; QAB-205; QAB 205; NVP-QAB-205-AA

IUPAC/Chemical Name: N-[4-[6-(Cyclobutylamino)-9H-purin-2-ylamino]phenyl]-N-methylacetamide Hydrochloride


InChi Code: InChI=1S/C18H21N7O.ClH/c1-11(26)25(2)14-8-6-13(7-9-14)22-18-23-16-15(19-10-20-16)17(24-18)21-12-4-3-5-12;/h6-10,12H,3-5H2,1-2H3,(H3,19,20,21,22,23,24);1H


Technical Data

Solid powder

>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:


1: MacGlashan D Jr. Marked differences in the signaling requirements for expression of CD203c and CD11b versus CD63 expression and histamine release in human basophils. Int Arch Allergy Immunol. 2012;159(3):243-52. doi: 10.1159/000332150. Epub 2012 Jun 20. PubMed PMID: 22722613; PubMed Central PMCID: PMC3533433.

2: Patou J, Holtappels G, Affleck K, van Cauwenberge P, Bachert C. Syk-kinase inhibition prevents mast cell activation in nasal polyps. Rhinology. 2011 Mar;49(1):100-6. doi: 10.4193/Rhino09.147. PubMed PMID: 21468383.

3: Havard S, Scola AM, Kay LJ, Ishmael SS, MacGlashan DW Jr, Peachell PT. Characterization of syk expression in human lung mast cells: relationship with function. Clin Exp Allergy. 2011 Mar;41(3):378-88. doi: 10.1111/j.1365-2222.2010.03667.x. Epub 2011 Jan 24. PubMed PMID: 21255137.

4: MacGlashan D Jr, Undem BJ. Inducing an anergic state in mast cells and basophils without secretion. J Allergy Clin Immunol. 2008 Jun;121(6):1500-6, 1506.e1-4. doi: 10.1016/j.jaci.2008.04.019. PubMed PMID: 18539198.