E2072

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564980

CAS#: 378242-00-3

Description: E2072 is a potent and selective thiol-based Glutamate Carboxypeptidase II (GCP-II) inhibitor.

Chemical Structure

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E2072
CAS# 378242-00-3
Instruction

Theoretical Analysis

MedKoo Cat#: 564980
Name: E2072
CAS#: 378242-00-3
Chemical Formula: C16H14O4S
Exact Mass: 302.06
Molecular Weight: 302.340
Elemental Analysis: C, 63.56; H, 4.67; O, 21.17; S, 10.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: E2072; E-2072; E 2072

IUPAC/Chemical Name: 3-(2-Mercaptoethyl)biphenyl-2,3'-dicarboxylic acid

InChi Key: FIILSNMCZCETMG-UHFFFAOYSA-N

InChi Code: InChI=1S/C16H14O4S/c17-15(18)12-5-1-4-11(9-12)13-6-2-3-10(7-8-21)14(13)16(19)20/h1-6,9,21H,7-8H2,(H,17,18)(H,19,20)

SMILES Code: O=C(C1=C(CCS)C=CC=C1C2=CC=CC(C(O)=O)=C2)O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 302.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wozniak KM, Wu Y, Vornov JJ, Lapidus R, Rais R, Rojas C, Tsukamoto T, Slusher BS. The orally active glutamate carboxypeptidase II inhibitor E2072 exhibits sustained nerve exposure and attenuates peripheral neuropathy. J Pharmacol Exp Ther. 2012 Dec;343(3):746-54. doi: 10.1124/jpet.112.197665. Epub 2012 Sep 17. PubMed PMID: 22988061.

2: Rais R, Hoover R, Wozniak K, Rudek MA, Tsukamoto T, Alt J, Rojas C, Slusher BS. Reversible disulfide formation of the glutamate carboxypeptidase II inhibitor E2072 results in prolonged systemic exposures in vivo. Drug Metab Dispos. 2012 Dec;40(12):2315-23. doi: 10.1124/dmd.112.046821. Epub 2012 Sep 4. PubMed PMID: 22949627; PubMed Central PMCID: PMC3500546.