NAcM-OPT
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555448

CAS#: 2089293-61-6

Description: NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM


Price and Availability

Size
Price

100mg
USD 450
1g
USD 2950
Size
Price

200mg
USD 850
2g
USD 4950
Size
Price

500mg
USD 1850
5g
USD 7450

NAcM-OPT, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555448
Name: NAcM-OPT
CAS#: 2089293-61-6
Chemical Formula: C23H29Cl2N3O
Exact Mass: 433.1688
Molecular Weight: 434.405
Elemental Analysis: C, 63.59; H, 6.73; Cl, 16.32; N, 9.67; O, 3.68


Synonym: NAcM-OPT; NAcM OPT; NAcMOPT;

IUPAC/Chemical Name: 1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea

InChi Key: VPHJABWIKCBGMC-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H29Cl2N3O/c1-2-3-13-27-14-11-20(12-15-27)28(17-18-7-5-4-6-8-18)23(29)26-19-9-10-21(24)22(25)16-19/h4-10,16,20H,2-3,11-15,17H2,1H3,(H,26,29)

SMILES Code: O=C(NC1=CC=C(Cl)C(Cl)=C1)N(CC2=CC=CC=C2)C3CCN(CCCC)CC3


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300


References

1: Scott DC, Hammill JT, Min J, Rhee DY, Connelly M, Sviderskiy VO, Bhasin D,
Chen Y, Ong SS, Chai SC, Goktug AN, Huang G, Monda JK, Low J, Kim HS, Paulo JA,
Cannon JR, Shelat AA, Chen T, Kelsall IR, Alpi AF, Pagala V, Wang X, Peng J,
Singh B, Harper JW, Schulman BA, Guy RK. Blocking an N-terminal
acetylation-dependent protein interaction inhibits an E3 ligase. Nat Chem Biol.
2017 Aug;13(8):850-857. doi: 10.1038/nchembio.2386. Epub 2017 Jun 5. PubMed PMID:
28581483; PubMed Central PMCID: PMC5577376.