NAcM-OPT
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555448

CAS#: 2089293-61-6

Description: NAcM-OPT is a specific, reversible small molecule inhibitor targeting N-Acetyl-UBE2M interaction with DCN1 with IC50 of 79 nM

Chemical Structure

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NAcM-OPT
CAS# 2089293-61-6
Instruction

Theoretical Analysis

MedKoo Cat#: 555448
Name: NAcM-OPT
CAS#: 2089293-61-6
Chemical Formula: C23H29Cl2N3O
Exact Mass: 433.17
Molecular Weight: 434.405
Elemental Analysis: C, 63.59; H, 6.73; Cl, 16.32; N, 9.67; O, 3.68

Price and Availability

Size Price Availability Quantity
100mg USD 450
200mg USD 850
500mg USD 1850
1g USD 2950
2g USD 4950
5g USD 7450
Bulk inquiry

Synonym: NAcM-OPT; NAcM OPT; NAcMOPT;

IUPAC/Chemical Name: 1-benzyl-1-(1-butylpiperidin-4-yl)-3-(3,4-dichlorophenyl)urea

InChi Key: VPHJABWIKCBGMC-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H29Cl2N3O/c1-2-3-13-27-14-11-20(12-15-27)28(17-18-7-5-4-6-8-18)23(29)26-19-9-10-21(24)22(25)16-19/h4-10,16,20H,2-3,11-15,17H2,1H3,(H,26,29)

SMILES Code: O=C(NC1=CC=C(Cl)C(Cl)=C1)N(CC2=CC=CC=C2)C3CCN(CCCC)CC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 434.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Scott DC, Hammill JT, Min J, Rhee DY, Connelly M, Sviderskiy VO, Bhasin D,
Chen Y, Ong SS, Chai SC, Goktug AN, Huang G, Monda JK, Low J, Kim HS, Paulo JA,
Cannon JR, Shelat AA, Chen T, Kelsall IR, Alpi AF, Pagala V, Wang X, Peng J,
Singh B, Harper JW, Schulman BA, Guy RK. Blocking an N-terminal
acetylation-dependent protein interaction inhibits an E3 ligase. Nat Chem Biol.
2017 Aug;13(8):850-857. doi: 10.1038/nchembio.2386. Epub 2017 Jun 5. PubMed PMID:
28581483; PubMed Central PMCID: PMC5577376.