WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564939
Description: Imanixil, also known as SAR-088 and HOE-402, is a PIP5K2B inhibitor. SAR088 showed reasonable potency, selectivity and physicochemical properties in enzymatic and cellular assays. In vivo, SAR088 lowered blood glucose levels of obese and hyperglycemic male Zucker diabetic fatty rats treated for 3 weeks. Thus, SAR088 represents the first orally available and in vivo active PIP5K2B inhibitor and provides an excellent starting point for the development of potent and selective PIP5K2B inhibitors for the treatment of insulin resistance and diabetes.
MedKoo Cat#: 564939
Chemical Formula: C17H17F3N6O2
Exact Mass: 394.1365
Molecular Weight: 394.36
Elemental Analysis: C, 51.78; H, 4.35; F, 14.45; N, 21.31; O, 8.11
This product is not in stock, which may be available by custom synthesis.
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Synonym: HOE-402; HOE 402; HOE402; SAR-088; SAR 088; SAR088; Imanixil
IUPAC/Chemical Name: 4-Amino-2-(4,4-dimethyl-2-oxoimidazolidin-1-yl)-N-(3-(trifluoromethyl)phenyl)pyrimidine-5-carboxamide
InChi Key: FUSNOPLQVRUIIM-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H17F3N6O2/c1-16(2)8-26(15(28)25-16)14-22-7-11(12(21)24-14)13(27)23-10-5-3-4-9(6-10)17(18,19)20/h3-7H,8H2,1-2H3,(H,23,27)(H,25,28)(H2,21,22,24)
SMILES Code: O=C(C1=CN=C(N2CC(C)(C)NC2=O)N=C1N)NC3=CC=CC(C(F)(F)F)=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 394.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
Voss MD, Czechtizky W, Li Z, Rudolph C, Petry S, Brummerhop H, Langer T, Schiffer A, Schaefer HL. Discovery and pharmacological characterization of a novel small molecule inhibitor of phosphatidylinositol-5-phosphate 4-kinase, type II, beta. Biochem Biophys Res Commun. 2014 Jul 4;449(3):327-31. doi: 10.1016/j.bbrc.2014.05.024. Epub 2014 May 15. PMID: 24845568.