AZD-8418
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MedKoo CAT#: 573395

CAS#: 1198309-73-7

Description: AZD-8418 is an mGlu2 receptor positive allosteric modulators that attenuates nicotine-taking and nicotine-seeking behavior. Acute treatment with AZD8418 (0.37, 1.12, 3.73, 7.46, and 14.92 mg/kg) and AZD8529 (1.75, 5.83, 17.5, and 58.3 mg/kg) deceased nicotine self-administration and had no effect on food-maintained responding. Chronic treatment with AZD8418 attenuated nicotine self-administration, but tolerance to this effect developed quickly. The inhibition of nicotine self-administration by chronic AZD8529 administration persisted throughout the 14 days of treatment. Chronic treatment with either PAMs inhibited food self-administration. AZD8418 (acute) and AZD8529 (acute and subchronic) blocked cue-induced reinstatement of nicotine- and food-seeking behavior.


Chemical Structure

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AZD-8418
CAS# 1198309-73-7

Theoretical Analysis

MedKoo Cat#: 573395
Name: AZD-8418
CAS#: 1198309-73-7
Chemical Formula: C19H20ClN3O3
Exact Mass: 373.12
Molecular Weight: 373.837
Elemental Analysis: C, 61.05; H, 5.39; Cl, 9.48; N, 11.24; O, 12.84

Price and Availability

Size Price Availability Quantity
1mg USD 150 Ready to Ship
5mg USD 450 Ready to Ship
10mg USD 750 Ready to Ship
25mg USD 1250 Ready to Ship
50mg USD 1950 Ready to Ship
100mg USD 3650 Ready to Ship
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Synonym: AZD-8418, AZD8418; AZD 8418;

IUPAC/Chemical Name: 5-(7-Chloro-2-((S)-1-cyclopropyl-ethyl)-1-oxo-2,3-dihydro-1H-isoindol-5-yl)-isoxazole-3-carboxylic acid dimethylamide

InChi Key: MCPBSUCAISQZQK-JTQLQIEISA-N

InChi Code: 1S/C19H20ClN3O3/c1-10(11-4-5-11)23-9-13-6-12(7-14(20)17(13)19(23)25)16-8-15(21-26-16)18(24)22(2)3/h6-8,10-11H,4-5,9H2,1-3H3/t10-/m0/s1

SMILES Code: C[C@@H](C1CC1)N2Cc3cc(cc(Cl)c3C2=O)c4onc(c4)C(=O)N(C)C

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target: AZD-8418 is an mGlu2 receptor positive allosteric modulator.
In vitro activity: TBD
In vivo activity: In vivo activity Acute treatment with AZD8418 (0.37, 1.12, 3.73, 7.46, and 14.92 mg/kg) and AZD8529 (1.75, 5.83, 17.5, and 58.3 mg/kg) deceased nicotine self-administration and had no effect on food-maintained responding in rats. Chronic treatment with AZD8418 attenuated nicotine self-administration, but tolerance to this effect developed quickly. Reference: Psychopharmacology (Berl). 2016 May;233(10):1801-14. https://pubmed.ncbi.nlm.nih.gov/26873083/

Preparing Stock Solutions

The following data is based on the product molecular weight 373.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Li X, D'Souza MS, Niño AM, Doherty J, Cross A, Markou A. Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats. Psychopharmacology (Berl). 2016 May;233(10):1801-14. doi: 10.1007/s00213-016-4220-2. Epub 2016 Feb 13. PMID: 26873083.
In vitro protocol: TBD
In vivo protocol: 1. Li X, D'Souza MS, Niño AM, Doherty J, Cross A, Markou A. Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats. Psychopharmacology (Berl). 2016 May;233(10):1801-14. doi: 10.1007/s00213-016-4220-2. Epub 2016 Feb 13. PMID: 26873083.

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1: Li X, D'Souza MS, Niño AM, Doherty J, Cross A, Markou A. Attenuation of nicotine-taking and nicotine-seeking behavior by the mGlu2 receptor positive allosteric modulators AZD8418 and AZD8529 in rats. Psychopharmacology (Berl). 2016 May;233(10):1801-14. doi: 10.1007/s00213-016-4220-2. Epub 2016 Feb 13. PubMed PMID: 26873083.