Taminadenant
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MedKoo CAT#: 584822

CAS#: 1337962-47-6 (free base)

Description: Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells.

Chemical Structure

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Taminadenant
CAS# 1337962-47-6 (free base)
Instruction

Theoretical Analysis

MedKoo Cat#: 584822
Name: Taminadenant
CAS#: 1337962-47-6 (free base)
Chemical Formula: C10H8BrN7
Exact Mass: 305.00
Molecular Weight: 306.127
Elemental Analysis: C, 39.24; H, 2.63; Br, 26.10; N, 32.03

Price and Availability

Size Price Availability Quantity
5mg USD 350 2 Weeks
10mg USD 550 2 Weeks
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Related CAS #: 1337962-47-6 (free base)   2253894-81-2 (mesylate)   2253894-80-1 (sulfate)   2253894-78-7 (HCl hydrate)   2253894-79-8 (HCl dihydrate)    

Synonym: PBF-509; PBF 509; PBF509; NIR-178; NIR 178; NIR178; Taminadenant;

IUPAC/Chemical Name: 5-bromo-2,6-di(1H-pyrazol-1-yl)pyrimidin-4-amine

InChi Key: ATFXVNUWQOXRRU-UHFFFAOYSA-N

InChi Code: InChI=1S/C10H8BrN7/c11-7-8(12)15-10(18-6-2-4-14-18)16-9(7)17-5-1-3-13-17/h1-6H,(H2,12,15,16)

SMILES Code: NC1=NC(N2N=CC=C2)=NC(N3N=CC=C3)=C1Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 306.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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