Aztreonam disodium

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MedKoo CAT#: 573372

CAS#: 80581-86-8

Description: Aztreonam disodium is a synthetic monocyclic beta-lactam antibiotic. It is resistant to beta-lactamases and is used in gram-negative infections, especially of the meninges, bladder, and kidneys. It may cause a superinfection with gram-positive organisms.


Chemical Structure

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Aztreonam disodium
CAS# 80581-86-8

Theoretical Analysis

MedKoo Cat#: 573372
Name: Aztreonam disodium
CAS#: 80581-86-8
Chemical Formula: C13H15N5Na2O8S2
Exact Mass: 479.02
Molecular Weight: 479.390
Elemental Analysis: C, 32.57; H, 3.15; N, 14.61; Na, 9.59; O, 26.70; S, 13.38

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Azactam disodium, Azthreonam disodium, Aztreonam disodium

IUPAC/Chemical Name: (Z)-2-((((2-Amino-4-thiazolyl)(((2S,3S)-2-methyl-4-oxo-1-sulfo-3-azetidinyl)carbamoyl)methylene)amino)oxy)-2-methylpropionic acid disodium salt

InChi Key: RXLLPYFOQJTFPY-VIQWXLMZSA-L

InChi Code: 1S/C13H17N5O8S2.2Na/c1-5-7(10(20)18(5)28(23,24)25)16-9(19)8(6-4-27-12(14)15-6)17-26-13(2,3)11(21)22;;/h4-5,7H,1-3H3,(H2,14,15)(H,16,19)(H,21,22)(H,23,24,25);;/q;2*+1/p-2/b17-8-;;/t5-,7-;;/m0../s1

SMILES Code: [Na+].[Na+].C[C@H]1[C@H](NC(=O)\C(=N/OC(C)(C)C(=O)[O-])\c2csc(N)n2)C(=O)N1S(=O)(=O)[O-]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 479.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Davido B, Dinh A, Senard O, Calin R, Makhloufi S, Salomon J. Repurposing an old drug: aztreonam as a new treatment strategy for gonorrhoea. J Antimicrob Chemother. 2017 May 1;72(5):1466-1468. doi: 10.1093/jac/dkw589. PubMed PMID: 28137938.

2: Bush K, Freudenberger JS, Sykes RB. Interaction of azthreonam and related monobactams with beta-lactamases from gram-negative bacteria. Antimicrob Agents Chemother. 1982 Sep;22(3):414-20. PubMed PMID: 6982680; PubMed Central PMCID: PMC183759.

3: Sykes RB, Bonner DP, Bush K, Georgopapadakou NH. Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria. Antimicrob Agents Chemother. 1982 Jan;21(1):85-92. PubMed PMID: 6979307; PubMed Central PMCID: PMC181833.