WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 555431
Description: NCC007 is a novel CKIα and CKIδ dual inhibitor. NCC007 that showed stronger period effects (0.32 μM for 5 h period lengthening) in a cellbased circadian assay. The following in vitro kinase assay showed that NCC007 inhibited CKIα and CKIδ with an IC50 of 1.8 and 3.6 μM. We further demonstrated that NCC007 lengthened the period of mouse behavioral rhythms in vivo. Thus, NCC007 is a valuable tool compound to control circadian rhythms through CKI inhibition.
MedKoo Cat#: 555431
Chemical Formula: C22H28F3N7
Exact Mass: 447.2358
Molecular Weight: 447.5102
Elemental Analysis: C, 59.05; H, 6.31; F, 12.74; N, 21.91
Synonym: NCC007; NCC-007; NCC 007;
IUPAC/Chemical Name: 9-(1-Cyclopropylethyl)-N2-(2-(dimethylamino)ethyl)-N6-(3-(trifluoromethyl)benzyl)-9H-purine-2,6-diamine
InChi Key: GHRNSZVMIARHIS-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H28F3N7/c1-14(16-7-8-16)32-13-28-18-19(29-21(30-20(18)32)26-9-10-31(2)3)27-12-15-5-4-6-17(11-15)22(23,24)25/h4-6,11,13-14,16H,7-10,12H2,1-3H3,(H2,26,27,29,30)
SMILES Code: FC(C1=CC(CNC2=C3N=CN(C(C4CC4)C)C3=NC(NCCN(C)C)=N2)=CC=C1)(F)F
Circadian rhythms are controlled by transcriptional feedback loops of clock genes and proteins. The stability of clock proteins is regulated by post-translational modification, such as phosphorylation by kinases. In particular, casein kinase I (CKI) phosphorylates the PER protein to regulate proteasomal degradation and nuclear localization. Therefore, CKI inhibition can modulate mammalian circadian rhythms.