L-4FPG
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MedKoo CAT#: 564895

CAS#: 19883-57-9

Description: L-4FPG is an inhibitor of the neutral amino acid transporters ASCT1 and ASCT2. L-4FPG shows good brain penetration and potently reduces amphetamine-induced hyperlocomotion.


Chemical Structure

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L-4FPG
CAS# 19883-57-9

Theoretical Analysis

MedKoo Cat#: 564895
Name: L-4FPG
CAS#: 19883-57-9
Chemical Formula: C8H8FNO2
Exact Mass: 169.0539
Molecular Weight: 169.16
Elemental Analysis: C, 56.80; H, 4.77; F, 11.23; N, 8.28; O, 18.92

Price and Availability

Size Price Availability Quantity
1.0g USD 480.0 Same day
5.0g USD 650.0 2 Weeks
10.0g USD 1050.0 2 Weeks
25.0g USD 1650.0 2 Weeks
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Synonym: L4FPG; L 4FPG; L-4FPG

IUPAC/Chemical Name: 2-(4-Fluorophenyl)-L-glycine

InChi Key: JKFYKCYQEWQPTM-ZETCQYMHSA-N

InChi Code: InChI=1S/C8H8FNO2/c9-6-3-1-5(2-4-6)7(10)8(11)12/h1-4,7H,10H2,(H,11,12)/t7-/m0/s1

SMILES Code: N[C@@H](C1=CC=C(F)C=C1)C(O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:

Certificate of Analysis:

Safety Data Sheet (SDS):

Biological target: L-4FPG is an inhibitor of the neutral amino acid transporters ASCT1 and ASCT2.
In vitro activity: TBD
In vivo activity: L-4FPG was tested for its effects on amphetamine-induced hyperlocomotion in a mouse model of schizophrenia. For L-4FPG (Fig. 3), a dose-dependent reduction was observed (overall treatment effect was significant by one-way ANOVA, F(4,34) = 3.07; P = 0.03) with a lowest effective dose for L-4FPG of 0.3 mg/kg (post hoc Dunnett’s test, P = 0.023); at 3 mg/kg the effect was not significant, indicating that a U-shaped dose-response relationship exists. Reference: J Pharmacol Exp Ther. 2018 Nov;367(2):292-301. https://jpet.aspetjournals.org/content/367/2/292.long

Preparing Stock Solutions

The following data is based on the product molecular weight 169.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol: 1. Li YX, Yang JY, Alcantara M, Abelian G, Kulkarni A, Staubli U, Foster AC. Inhibitors of the Neutral Amino Acid Transporters ASCT1 and ASCT2 Are Effective in In Vivo Models of Schizophrenia and Visual Dysfunction. J Pharmacol Exp Ther. 2018 Nov;367(2):292-301. doi: 10.1124/jpet.118.251116. Epub 2018 Aug 31. PMID: 30171039.
In vitro protocol: TBD
In vivo protocol: 1. Li YX, Yang JY, Alcantara M, Abelian G, Kulkarni A, Staubli U, Foster AC. Inhibitors of the Neutral Amino Acid Transporters ASCT1 and ASCT2 Are Effective in In Vivo Models of Schizophrenia and Visual Dysfunction. J Pharmacol Exp Ther. 2018 Nov;367(2):292-301. doi: 10.1124/jpet.118.251116. Epub 2018 Aug 31. PMID: 30171039.

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1: Li YX, Yang JY, Alcantara M, Abelian G, Kulkarni A, Staubli U, Foster AC. Inhibitors of the Neutral Amino Acid Transporters ASCT1 and ASCT2 Are Effective in In Vivo Models of Schizophrenia and Visual Dysfunction. J Pharmacol Exp Ther. 2018 Nov;367(2):292-301. doi: 10.1124/jpet.118.251116. Epub 2018 Aug 31. PubMed PMID: 30171039.