UTKO1

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564873

CAS#: 150810-68-7

Description: UTKO1 is a selective inhibitor of notochord tubulogenesis which prevents 14-3-3εa from interacting with ezrin/radixin/moesin (ERM).

Chemical Structure

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UTKO1
CAS# 150810-68-7
Instruction

Theoretical Analysis

MedKoo Cat#: 564873
Name: UTKO1
CAS#: 150810-68-7
Chemical Formula: C23H34O4
Exact Mass: 374.25
Molecular Weight: 374.520
Elemental Analysis: C, 73.76; H, 9.15; O, 17.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: UTKO-1; UTKO 1; UTKO1

IUPAC/Chemical Name: 2,4-Dihydroxy-3-(2-hydroxy-3-methylene-5-(cis-2,2,6-trimethylcyclohexyl)pentyl)-6-methylbenzaldehyde

InChi Key: YOVCMWYBBMXELB-ROUURWLGSA-N

InChi Code: InChI=1S/C23H34O4/c1-14-7-6-10-23(4,5)19(14)9-8-15(2)20(25)12-17-21(26)11-16(3)18(13-24)22(17)27/h11,13-14,19-20,25-27H,2,6-10,12H2,1,3-5H3/t14-,19-,20?/m1/s1

SMILES Code: O=CC1=C(C)C=C(O)C(CC(O)C(CC[C@H]2C(C)(C)CCC[C@H]2C)=C)=C1O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 374.52 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Mizotani Y, Suzuki M, Hotta K, Watanabe H, Shiba K, Inaba K, Tashiro E, Oka K, Imoto M. 14-3-3εa directs the pulsatile transport of basal factors toward the apical domain for lumen growth in tubulogenesis. Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):E8873-E8881. doi: 10.1073/pnas.1808756115. Epub 2018 Aug 29. PubMed PMID: 30158171; PubMed Central PMCID: PMC6156656.

2: Tashiro E, Imoto M. Chemistry and biology of the compounds that modulate cell migration. J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):213-9. doi: 10.1007/s10295-015-1654-1. Epub 2015 Jul 15. Review. PubMed PMID: 26173498.

3: Kobayashi H, Ogura Y, Sawada M, Nakayama R, Takano K, Minato Y, Takemoto Y, Tashiro E, Watanabe H, Imoto M. Involvement of 14-3-3 proteins in the second epidermal growth factor-induced wave of Rac1 activation in the process of cell migration. J Biol Chem. 2011 Nov 11;286(45):39259-68. doi: 10.1074/jbc.M111.255489. Epub 2011 Aug 25. PubMed PMID: 21868386; PubMed Central PMCID: PMC3234750.

4: Sawada M, Kubo S, Matsumura K, Takemoto Y, Kobayashi H, Tashiro E, Kitahara T, Watanabe H, Imoto M. Synthesis and anti-migrative evaluation of moverastin derivatives. Bioorg Med Chem Lett. 2011 Mar 1;21(5):1385-9. doi: 10.1016/j.bmcl.2011.01.028. Epub 2011 Jan 11. PubMed PMID: 21306898.