Nutlin-3
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 471022

CAS#: 548472-68-0 (4R5S, and 4S5R)

Description: Nutlin-3 is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin-3 activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein.


Price and Availability

Size
Price

100mg
USD 750
1g
USD 3250
Size
Price

200mg
USD 1350
2g
USD 4650
Size
Price

500mg
USD 2150
5g
USD 6950

Nutlin-3, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 471022
Name: Nutlin-3
CAS#: 548472-68-0 (4R5S, and 4S5R)
Chemical Formula: C30H30Cl2N4O4
Exact Mass: 580.1644
Molecular Weight: 581.494
Elemental Analysis: C, 61.97; H, 5.20; Cl, 12.19; N, 9.64; O, 11.01


Related CAS #: 675576-98-4 (4S5R)   548472-68-0 (4R5S   and 4S5R)   675576-97-3(4R5S   Nutlin 3b)  

Synonym: (±)-Nutlin-3, Nutlin-3, Nutlin 3

IUPAC/Chemical Name: (±)-4-[4,5-bis-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

InChi Key: BDUHCSBCVGXTJM-WUFINQPMSA-N

InChi Code: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1

SMILES Code: ClC1=CC=C([C@H]2[C@H](N(C(C3=CC=C(C=C3OC(C)C)OC)=N2)C(N4CCN(C(C4)=O)[H])=O)C5=CC=C(C=C5)Cl)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

Harmonized System Code:
2934990300