Nutlin-3
featured

We are open as normal during COVID-19 pandemic. Order online, same day shipping out from North Carolina, USA

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 471022

CAS#: 548472-68-0 (4R5S, and 4S5R)

Description: Nutlin-3 is an inhibitor of MDM2 (human homolog of murine double minute 2), which disrupts its interaction with p53, leading to the stabilization and activation of p53. Nutlin-3 activates the p53 pathway and efficiently induces apoptosis in tumours with amplified MDM2 gene and overexpression of MDM2 protein.


Price and Availability

Size Price Shipping out time Quantity
100mg USD 750 2 Weeks
200mg USD 1350 2 Weeks
500mg USD 2150 2 Weeks
1g USD 3250 2 Weeks
2g USD 4650 2 Weeks
5g USD 6950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-08-09. Prices are subject to change without notice.

Nutlin-3, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

img

Theoretical Analysis

MedKoo Cat#: 471022
Name: Nutlin-3
CAS#: 548472-68-0 (4R5S, and 4S5R)
Chemical Formula: C30H30Cl2N4O4
Exact Mass: 580.1644
Molecular Weight: 581.494
Elemental Analysis: C, 61.97; H, 5.20; Cl, 12.19; N, 9.64; O, 11.01


Related CAS #: 675576-98-4 (4S5R)   548472-68-0 (4R5S   and 4S5R)   675576-97-3(4R5S   Nutlin 3b)  

Synonym: (±)-Nutlin-3, Nutlin-3, Nutlin 3

IUPAC/Chemical Name: (±)-4-[4,5-bis-(4-chlorophenyl)-2-(2-isopropoxy-4-methoxy-phenyl)-4,5-dihydro-imidazole-1-carbonyl]-piperazin-2-one

InChi Key: BDUHCSBCVGXTJM-WUFINQPMSA-N

InChi Code: InChI=1S/C30H30Cl2N4O4/c1-18(2)40-25-16-23(39-3)12-13-24(25)29-34-27(19-4-8-21(31)9-5-19)28(20-6-10-22(32)11-7-20)36(29)30(38)35-15-14-33-26(37)17-35/h4-13,16,18,27-28H,14-15,17H2,1-3H3,(H,33,37)/t27-,28+/m0/s1

SMILES Code: ClC1=CC=C([C@H]2[C@H](N(C(C3=CC=C(C=C3OC(C)C)OC)=N2)C(N4CCN(C(C4)=O)[H])=O)C5=CC=C(C=C5)Cl)C=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001