WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564852
CAS#: 825608-40-0
Description: IKKß-IN-124 is an allosteric inhibitor of IκBα phosphorylation and NF-κB transcriptional activity through selective capture of the inactive conformation and hence blockade of IKKβ S177/S181 phosphorylation.
MedKoo Cat#: 564852
Name: IKKß-IN-124
CAS#: 825608-40-0
Chemical Formula: C17H26Cl2N2O3S
Exact Mass: 408.1041
Molecular Weight: 409.37
Elemental Analysis: C, 49.88; H, 6.40; Cl, 17.32; N, 6.84; O, 11.72; S, 7.83
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Synonym: IKKßIN-124; IKKß-IN124; IKKß IN-124; IKKß-IN 124; IKKßIN124; IKKß-IN-124
IUPAC/Chemical Name: 3,4-Dichloro-2-ethoxy-N-(2,2,6,6-tetramethylpiperidin-4-yl)benzenesulfonamide
InChi Key: FOHQZHZDYGDEOI-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H26Cl2N2O3S/c1-6-24-15-13(8-7-12(18)14(15)19)25(22,23)20-11-9-16(2,3)21-17(4,5)10-11/h7-8,11,20-21H,6,9-10H2,1-5H3
SMILES Code: O=S(C1=CC=C(Cl)C(Cl)=C1OCC)(NC2CC(C)(C)NC(C)(C)C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 409.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |