WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 564847
CAS#: 6901-60-6 (racemic)
Description: Saringosterol, also known as Saningosterol and Cystosphaerol, is a selective LXRβ agonist. Saringosterol is racmic at the 24-position.
MedKoo Cat#: 564847
CAS#: 6901-60-6 (racemic)
Chemical Formula: C29H48O2
Exact Mass: 428.3654
Molecular Weight: 428.7
Elemental Analysis: C, 81.25; H, 11.29; O, 7.46
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Related CAS #: 6901-60-6 (racemic) 87859-98-1 (24S-isomer) 87859-99-2 (24R-isomer)
Synonym: Saningosterol; Saringosterol; Seringosterol; Cystosphaerol;
IUPAC/Chemical Name: (3S,8S,9S,10R,13R,14S,17R)-17-((2R)-5-hydroxy-5-isopropylhept-6-en-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol
InChi Key: OPGVEUGCNGNPSX-SVSQYMGHSA-N
InChi Code: InChI=1S/C29H48O2/c1-7-29(31,19(2)3)17-12-20(4)24-10-11-25-23-9-8-21-18-22(30)13-15-27(21,5)26(23)14-16-28(24,25)6/h7-8,19-20,22-26,30-31H,1,9-18H2,2-6H3/t20-,22+,23+,24-,25+,26+,27+,28-,29?/m1/s1
SMILES Code: O[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H]([C@@H](CCC(C(C)C)(C=C)O)C)CC[C@@]4([H])[C@]3([H])CC=C2C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 428.7 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Chen Z, Liu J, Fu Z, Ye C, Zhang R, Song Y, Zhang Y, Li H, Ying H, Liu H. 24(S)-Saringosterol from edible marine seaweed Sargassum fusiforme is a novel selective LXRβ agonist. J Agric Food Chem. 2014 Jul 2;62(26):6130-7. doi: 10.1021/jf500083r. Epub 2014 Jun 20. PubMed PMID: 24927286.
2: Castro Navas FF, Giorgi G, Maggioni D, Pacciarini M, Russo V, Marinozzi M. C24-hydroxylated stigmastane derivatives as Liver X Receptor agonists. Chem Phys Lipids. 2018 May;212:44-50. doi: 10.1016/j.chemphyslip.2018.01.005. Epub 2018 Jan 17. PubMed PMID: 29352964.
3: Feng MT, Wang T, Liu AH, Li J, Yao LG, Wang B, Guo YW, Mao SC. PTP1B inhibitory and cytotoxic C-24 epimers of Δ(28)-24-hydroxy stigmastane-type steroids from the brown alga Dictyopteris undulata Holmes. Phytochemistry. 2018 Feb;146:25-35. doi: 10.1016/j.phytochem.2017.11.013. Epub 2017 Dec 22. PubMed PMID: 29207320.