VUF14480

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 555418

CAS#: 1605304-31-1

Description: VUF14480 is a covalent partial agonist that interacts with cysteine 98(3.36) of the human histamine H₄ receptor. VUF14480 was shown to be a partial agonist of hH4 receptor-mediated G protein signalling and β-arrestin2 recruitment. VUF14480 bound covalently to the hH₄ receptor with submicromolar affinity. Serine substitution of C98(3.36) prevented this covalent interaction.

Chemical Structure

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VUF14480
CAS# 1605304-31-1
Instruction

Theoretical Analysis

MedKoo Cat#: 555418
Name: VUF14480
CAS#: 1605304-31-1
Chemical Formula: C17H20N4
Exact Mass: 280.17
Molecular Weight: 280.375
Elemental Analysis: C, 72.83; H, 7.19; N, 19.98

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: VUF14480; VU-F14480; VUF 14480;

IUPAC/Chemical Name: 4-(4-Methylpiperazin-1-yl)-6-phenyl-2-vinylpyrimidine

InChi Key: IQEYEGMWJXOFAC-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20N4/c1-3-16-18-15(14-7-5-4-6-8-14)13-17(19-16)21-11-9-20(2)10-12-21/h3-8,13H,1,9-12H2,2H3

SMILES Code: C=CC1=NC(C2=CC=CC=C2)=CC(N3CCN(C)CC3)=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 280.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nijmeijer S, Engelhardt H, Schultes S, van de Stolpe AC, Lusink V, de Graaf C,
Wijtmans M, Haaksma EE, de Esch IJ, Stachurski K, Vischer HF, Leurs R. Design and
pharmacological characterization of VUF14480, a covalent partial agonist that
interacts with cysteine 98(3.36) of the human histamine H₄ receptor. Br J
Pharmacol. 2013 Sep;170(1):89-100. doi: 10.1111/bph.12113. PubMed PMID: 23347159;
PubMed Central PMCID: PMC3764852.