Sulfuretin

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573329

CAS#: 120-05-8

Description: Sulfuretin is a potent antioxidant that is reported to be beneficial in the treatment of neurodegenerative diseases. In one study, Sulfuretin attenuated MPP⁺-induced neurotoxicity through Akt/GSK3β and ERK signaling pathways. This drug may also have therapeutic activity against acquired lymphedema by reducing adipogenesis.

Chemical Structure

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Sulfuretin
CAS# 120-05-8
Instruction

Theoretical Analysis

MedKoo Cat#: 573329
Name: Sulfuretin
CAS#: 120-05-8
Chemical Formula: C15H10O5
Exact Mass: 270.05
Molecular Weight: 270.240
Elemental Analysis: C, 66.67; H, 3.73; O, 29.60

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Sulfuretin

IUPAC/Chemical Name: (Z)-2-((3,4-Dihydroxyphenyl)methylene)-6-hydroxy-2H-benzofuran-3-one

InChi Key: RGNXWPVNPFAADO-NSIKDUERSA-N

InChi Code: 1S/C15H10O5/c16-9-2-3-10-13(7-9)20-14(15(10)19)6-8-1-4-11(17)12(18)5-8/h1-7,16-18H/b14-6-

SMILES Code: Oc1ccc2C(=O)\C(=C\c3ccc(O)c(O)c3)\Oc2c1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 270.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jiang P, Sun H. Sulfuretin alleviates atopic dermatitis-like symptoms in mice via suppressing Th2 cell activity. Immunol Res. 2018 Oct;66(5):611-619. doi: 10.1007/s12026-018-9025-4. PubMed PMID: 30159861.

2: Pariyar R, Lamichhane R, Jung HJ, Kim SY, Seo J. Sulfuretin Attenuates MPP⁺-Induced Neurotoxicity through Akt/GSK3β and ERK Signaling Pathways. Int J Mol Sci. 2017 Dec 19;18(12). pii: E2753. doi: 10.3390/ijms18122753. PubMed PMID: 29257079; PubMed Central PMCID: PMC5751352.

3: Roh K, Kim S, Kang H, Ku JM, Park KW, Lee S. Sulfuretin has therapeutic activity against acquired lymphedema by reducing adipogenesis. Pharmacol Res. 2017 Jul;121:230-239. doi: 10.1016/j.phrs.2017.05.003. Epub 2017 May 5. PubMed PMID: 28483479.

4: Song NJ, Kwon SM, Kim S, Yoon HJ, Seo CR, Jang B, Chang SH, Ku JM, Lee JS, Park KM, Hong JW, Kim GH, Park KW. Sulfuretin induces osteoblast differentiation through activation of TGF-β signaling. Mol Cell Biochem. 2015 Dec;410(1-2):55-63. doi: 10.1007/s11010-015-2537-5. Epub 2015 Aug 11. PubMed PMID: 26260053.

5: Kwon SH, Ma SX, Hwang JY, Lee SY, Jang CG. Involvement of the Nrf2/HO-1 signaling pathway in sulfuretin-induced protection against amyloid beta25-35 neurotoxicity. Neuroscience. 2015 Sep 24;304:14-28. doi: 10.1016/j.neuroscience.2015.07.030. Epub 2015 Jul 17. PubMed PMID: 26192096.

6: Lee DS, Kim KS, Ko W, Li B, Jeong GS, Jang JH, Oh H, Kim YC. The cytoprotective effect of sulfuretin against tert-butyl hydroperoxide-induced hepatotoxicity through Nrf2/ARE and JNK/ERK MAPK-mediated heme oxygenase-1 expression. Int J Mol Sci. 2014 May 19;15(5):8863-77. doi: 10.3390/ijms15058863. PubMed PMID: 24857917; PubMed Central PMCID: PMC4057764.

7: Kwon SH, Ma SX, Lee SY, Jang CG. Sulfuretin inhibits 6-hydroxydopamine-induced neuronal cell death via reactive oxygen species-dependent mechanisms in human neuroblastoma SH-SY5Y cells. Neurochem Int. 2014 Jul;74:53-64. doi: 10.1016/j.neuint.2014.04.016. Epub 2014 May 4. PubMed PMID: 24801546.