UM171

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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564798

CAS#: 1448724-09-1

Description: UM171 is a potent agonist of human hematopoietic stem cell self-renewal.


Price and Availability

Size Price Shipping out time Quantity
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Pricing updated 2020-10-30. Prices are subject to change without notice.

UM171 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564798
Name: UM171
CAS#: 1448724-09-1
Chemical Formula: C25H27N9
Exact Mass: 453.2389
Molecular Weight: 453.55
Elemental Analysis: C, 66.20; H, 6.00; N, 27.79


Synonym: UM-171; UM 171; UM171

IUPAC/Chemical Name: (1r,4r)-N1-(2-Benzyl-7-(2-methyl-2H-tetrazol-5-yl)-9H-pyrimido[4,5-b]indol-4-yl)cyclohexane-1,4-diamine

InChi Key: AZXXGVPWWKWGAE-IYARVYRRSA-N

InChi Code: InChI=1S/C25H27N9/c1-34-32-23(31-33-34)16-7-12-19-20(14-16)28-25-22(19)24(27-18-10-8-17(26)9-11-18)29-21(30-25)13-15-5-3-2-4-6-15/h2-7,12,14,17-18H,8-11,13,26H2,1H3,(H2,27,28,29,30)/t17-,18-

SMILES Code: N[C@H]1CC[C@H](NC2=C3C(NC4=C3C=CC(C5=NN(C)N=N5)=C4)=NC(CC6=CC=CC=C6)=N2)CC1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Charlesworth CT, Camarena J, Cromer MK, Vaidyanathan S, Bak RO, Carte JM, Potter J, Dever DP, Porteus MH. Priming Human Repopulating Hematopoietic Stem and Progenitor Cells for Cas9/sgRNA Gene Targeting. Mol Ther Nucleic Acids. 2018 Sep 7;12:89-104. doi: 10.1016/j.omtn.2018.04.017. Epub 2018 May 3. PubMed PMID: 30195800; PubMed Central PMCID: PMC6023838.

2: Ngom M, Imren S, Maetzig T, Adair JE, Knapp DJHF, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RK. UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells. Mol Ther Methods Clin Dev. 2018 Jul 5;10:156-164. doi: 10.1016/j.omtm.2018.06.009. eCollection 2018 Sep 21. PubMed PMID: 30101153; PubMed Central PMCID: PMC6077133.

3: Li X, Xia C, Wang T, Liu L, Zhao Q, Yang D, Hu F, Zhang M, Huang K, Geng Y, Zheng Y, Guan Y, Wu H, Chen X, Pan G, Chen J, Du J, Wang J. Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. Stem Cell Res. 2017 May;21:32-39. doi: 10.1016/j.scr.2017.03.014. Epub 2017 Mar 21. PubMed PMID: 28368243.

4: Lahlil R, Scrofani M, Barbet R, Tancredi C, Aries A, Hénon P. VSELs Maintain their Pluripotency and Competence to Differentiate after Enhanced Ex Vivo Expansion. Stem Cell Rev. 2018 May 8. doi: 10.1007/s12015-018-9821-1. [Epub ahead of print] PubMed PMID: 29736843; PubMed Central PMCID: PMC6013546.

5: Psatha N, Georgolopoulos G, Phelps S, Papayannopoulou T. Brief Report: A Differential Transcriptomic Profile of Ex Vivo Expanded Adult Human Hematopoietic Stem Cells Empowers Them for Engraftment Better than Their Surface Phenotype. Stem Cells Transl Med. 2017 Oct;6(10):1852-1858. doi: 10.1002/sctm.17-0048. Epub 2017 Aug 11. PubMed PMID: 28801972.

6: Fares I, Chagraoui J, Lehnertz B, MacRae T, Mayotte N, Tomellini E, Aubert L, Roux PP, Sauvageau G. EPCR expression marks UM171-expanded CD34(+) cord blood stem cells. Blood. 2017 Jun 22;129(25):3344-3351. doi: 10.1182/blood-2016-11-750729. Epub 2017 Apr 13. PubMed PMID: 28408459.