NSC145366

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MedKoo CAT#: 564779

CAS#: 1052515-37-3

Description: NSC145366 is an inhibitor of Hsp90 activities which targets the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation. NSC145366 increases Hsp90 oligomerization resulting in allosteric inhibition of NTD ATPase activity (IC50=119μM) but does not compete with NTD or CTD-ATP binding.


Price and Availability

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Pricing updated 2020-08-03. Prices are subject to change without notice.

NSC145366 is not in stock, may be available through custom synthesis. For cost-effective reason, minimum 1 gram order is requested. The product will be characterized by NMR, HPLC and MS analysis. Purity (HPLC) is usually >98%. CoA, QC data, MSDS will be provided when product is successfully made. The estimated lead time is 2-3 months. Please send email to sales@medkoo.com to inquire quote.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 564779
Name: NSC145366
CAS#: 1052515-37-3
Chemical Formula: C37H64Cl2N2O4
Exact Mass:
Molecular Weight: 671.83
Elemental Analysis: C, 66.15; H, 9.60; Cl, 10.55; N, 4.17; O, 9.53


Synonym: NSC-145366; NSC 145366; NSC145366

IUPAC/Chemical Name: 2,2-Bis(4-[2-Hydroxy-3-(1,1,3,3-tetramethyl-butylamino)-propoxy]-phenyl)propane dihydrochloride

InChi Key: VIFJFGHDOMDVRZ-UHFFFAOYSA-N

InChi Code: InChI=1S/C37H62N2O4.2ClH/c1-33(2,3)25-35(7,8)38-21-29(40)23-42-31-17-13-27(14-18-31)37(11,12)28-15-19-32(20-16-28)43-24-30(41)22-39-36(9,10)26-34(4,5)6;;/h13-20,29-30,38-41H,21-26H2,1-12H3;2*1H

SMILES Code: CC(C1=CC=C(OCC(O)CNC(C)(C)CC(C)(C)C)C=C1)(C2=CC=C(OCC(O)CNC(C)(C)CC(C)(C)C)C=C2)C.[H]Cl.[H]Cl


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Thomas FM, Goode KM, Rajwa B, Bieberich AA, Avramova LV, Hazbun TR, Davisson VJ. A Chemogenomic Screening Platform Used to Identify Chemotypes Perturbing HSP90 Pathways. SLAS Discov. 2017 Jul;22(6):706-719. doi: 10.1177/2472555216687525. Epub 2017 Jan 31. PubMed PMID: 28346089.

2: Goode KM, Petrov DP, Vickman RE, Crist SA, Pascuzzi PE, Ratliff TL, Davisson VJ, Hazbun TR. Targeting the Hsp90 C-terminal domain to induce allosteric inhibition and selective client downregulation. Biochim Biophys Acta Gen Subj. 2017 Aug;1861(8):1992-2006. doi: 10.1016/j.bbagen.2017.05.006. Epub 2017 May 8. PubMed PMID: 28495207.