L48H37
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 564775

CAS#: 343307-76-6

Description: L48H37 is a specific myeloid differentiation 2 (MD2) inhibitor.


Chemical Structure

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L48H37
CAS# 343307-76-6

Theoretical Analysis

MedKoo Cat#: 564775
Name: L48H37
CAS#: 343307-76-6
Chemical Formula: C27H33NO7
Exact Mass: 483.2257
Molecular Weight: 483.56
Elemental Analysis: C, 67.06; H, 6.88; N, 2.90; O, 23.16

Price and Availability

Size Price Availability Quantity
5.0mg USD 270.0 2 Weeks
25.0mg USD 650.0 2 Weeks
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Synonym: L48-H37; L48 H37; L48H37

IUPAC/Chemical Name: 1-Ethyl-3,5-bis(3,4,5-trimethoxybenzylidene)piperidin-4-one

InChi Key: IOFNKUXFKVPLPF-LQGKIZFRSA-N

InChi Code: InChI=1S/C27H33NO7/c1-8-28-15-19(9-17-11-21(30-2)26(34-6)22(12-17)31-3)25(29)20(16-28)10-18-13-23(32-4)27(35-7)24(14-18)33-5/h9-14H,8,15-16H2,1-7H3/b19-9+,20-10+

SMILES Code: O=C1/C(CN(CC)C/C1=C\C2=CC(OC)=C(OC)C(OC)=C2)=C/C3=CC(OC)=C(OC)C(OC)=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 483.56 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Correction to "Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2". J Pharmacol Exp Ther. 2018 Apr;365(1):201. doi: 10.1124/jpet.117.222570err. PubMed PMID: 29559582.

2: Feng C, Xia Y, Zou P, Shen M, Hu J, Ying S, Pan J, Liu Z, Dai X, Zhuge W, Liang G, Ruan Y. Curcumin analog L48H37 induces apoptosis through ROS-mediated endoplasmic reticulum stress and STAT3 pathways in human lung cancer cells. Mol Carcinog. 2017 Jul;56(7):1765-1777. doi: 10.1002/mc.22633. Epub 2017 Mar 10. PubMed PMID: 28218464.

3: Wang Y, Shan X, Dai Y, Jiang L, Chen G, Zhang Y, Wang Z, Dong L, Wu J, Guo G, Liang G. Curcumin Analog L48H37 Prevents Lipopolysaccharide-Induced TLR4 Signaling Pathway Activation and Sepsis via Targeting MD2. J Pharmacol Exp Ther. 2015 Jun;353(3):539-50. doi: 10.1124/jpet.115.222570. Epub 2015 Apr 10. Erratum in: J Pharmacol Exp Ther. 2018 Apr;365(1):201. PubMed PMID: 25862641.

L48H37

5.0mg / USD 270.0