WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 573278

CAS#: 71939-51-0

Description: alpha-Artemether is a Quinghaosu derivative which shows antimalarial and antifungal activity.

Chemical Structure

CAS# 71939-51-0

Theoretical Analysis

MedKoo Cat#: 573278
Name: alpha-Artemether
CAS#: 71939-51-0
Chemical Formula: C16H26O5
Exact Mass: 298.178
Molecular Weight: 298.38
Elemental Analysis: C, 64.41; H, 8.78; O, 26.81

Price and Availability

Size Price Availability Quantity
25.0mg USD 320.0 2 Weeks
250.0mg USD 1600.0 2 Weeks
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Synonym: alpha-Artemether

IUPAC/Chemical Name: 3,12-Epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin, decahydro-10-methoxy-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10R,12R,12aR)-


InChi Code: 1S/C16H26O5/c1-9-5-6-12-10(2)13(17-4)18-14-16(12)11(9)7-8-15(3,19-14)20-21-16/h9-14H,5-8H2,1-4H3/t9-,10-,11+,12+,13-,14-,15-,16-/m1/s1

SMILES Code: O1[C@H]([C@@H]([C@@H]2CC[C@H](C)[C@@H]3CC[C@@]4(O[C@H]1[C@@]23OO4)C)C)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 298.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Tian L, Liu J, Jia Q, Ying Y, Yang Z, Huang G. Preparation and Evaluation of Artemether Liposomes for Enhanced Anti-Tumor Therapy. AAPS PharmSciTech. 2018 Feb;19(2):512-521. doi: 10.1208/s12249-017-0896-9. Epub 2017 Oct 16. PubMed PMID: 29038986.

2: Abd El-Aal NF, Hamza RS, Magdy M. Anti-angiogenic and anti-lymphangiogenic role of praziquantel and artemether in experimental mansoniasis. Acta Parasitol. 2017 Dec 20;62(4):708-716. doi: 10.1515/ap-2017-0085. PubMed PMID: 29035850.

3: Tan WQ, Chen G, Ye M, Jia B. Artemether Regulates Chemosensitivity to Doxorubicin via Regulation of B7-H3 in Human Neuroblastoma Cells. Med Sci Monit. 2017 Sep 3;23:4252-4259. PubMed PMID: 28866709; PubMed Central PMCID: PMC5594998.

4: Okorji UP, Velagapudi R, El-Bakoush A, Fiebich BL, Olajide OA. Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms. Mol Neurobiol. 2016 Nov;53(9):6426-6443. doi: 10.1007/s12035-015-9543-1. Epub 2015 Nov 25. PubMed PMID: 26607631.

5: Esu E, Effa EE, Opie ON, Uwaoma A, Meremikwu MM. Artemether for severe malaria. Cochrane Database Syst Rev. 2014 Sep 11;(9):CD010678. doi: 10.1002/14651858.CD010678.pub2. Review. PubMed PMID: 25209020; PubMed Central PMCID: PMC4455227.