WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 584753
CAS#: 261365-11-1
Description: MB 05032 is a potent FBPase inhibitor that promotes HSC expansion.
MedKoo Cat#: 584753
Name: MB 05032
CAS#: 261365-11-1
Chemical Formula: C11H15N2O4PS
Exact Mass: 302.049
Molecular Weight: 302.2848
Elemental Analysis: C, 43.71; H, 5.00; N, 9.27; O, 21.17; P, 10.25; S, 10.61
Synonym: MB 05032; MB05032; MB-05032
IUPAC/Chemical Name: P-[5-[2-Amino-5-(2-methylpropyl)-4-thiazolyl]-2-furanyl]phosphonic acid
InChi Key: XJMYIJPPDSZOPN-UHFFFAOYSA-N
InChi Code: InChI=1S/C11H15N2O4PS/c1-6(2)5-8-10(13-11(12)19-8)7-3-4-9(17-7)18(14,15)16/h3-4,6H,5H2,1-2H3,(H2,12,13)(H2,14,15,16)
SMILES Code: OP(O)(C1=CC=C(C2=C(CC(C)C)SC(N)=N2)O1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 302.2848 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Guo et al (2018) Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis. Nat.Med. 24 360 PMID: 29377004
van Poelje et al (2011) Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes. Handb.Exp.Pharmacol. 203 279 PMID: 21484576
