MT 0703

    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 584750

CAS#: 108353-14-6

Description: MT 0703 is an aminothiazolylglycylcephalosporin antibiotic.


Chemical Structure

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MT 0703
CAS# 108353-14-6

Theoretical Analysis

MedKoo Cat#: 584750
Name: MT 0703
CAS#: 108353-14-6
Chemical Formula: C26H28N7O11S3
Exact Mass: 710.1009
Molecular Weight: 710.728
Elemental Analysis: C, 43.94; H, 3.97; N, 13.80; O, 24.76; S, 13.53

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: MT 0703; Antibiotic MT 0703; MT0703

IUPAC/Chemical Name: Pyridinium, 4-(((7-(((2-amino-4-thiazolyl)(((1,4-dihydro-1,5-dihydroxy-1,5-dihydroxy-4-oxo-2-pyridinyl)carbonyl)amino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)thio)-1-(2-hydroxyethyl)-, hydroxide, inner salt, (6R-(6alpha,7beta))-

InChi Key: FQRIHMKPNWMVCQ-ZAZMHIJSSA-N

InChi Code: InChI=1S/C26H28N7O11S3/c27-25-28-14(10-47-25)17(29-20(36)15-7-16(35)26(41,42)11-33(15,43)44)21(37)30-18-22(38)32-19(24(39)40)12(9-46-23(18)32)8-45-13-1-3-31(4-2-13)5-6-34/h1-4,7,10,17-18,23,34,41-44H,5-6,8-9,11H2,(H4-,27,28,29,30,36,37,39,40)/t17?,18-,23-/m1/s1

SMILES Code: OCC[N+]1=CC=C(SCC(CS[C@]2([H])[C@@H]3NC(C(C4=CSC(N)=N4)NC(C5=CC(C(O)(O)C[N]5(O)O)=O)=O)=O)=C(C([O-])=O)N2C3=O)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Preparing Stock Solutions

The following data is based on the product molecular weight 710.728 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL

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1: Holihan JL, Chen JS, Greenberg J, Hehir D, Johnston SM, Marcus D, Ryan H, Tsuda S, Liang MK. Incidence of Port-Site Hernias: A Survey and Literature Review. Surg Laparosc Endosc Percutan Tech. 2016 Dec;26(6):425-430. Review. PubMed PMID: 27846177.

2: Numata G, Amiya E, Kojima T, Fujiu K, Hatano M, Watanabe M, Komuro I. Cardiac Resynchronization Therapy in Patients with Ebstein's Anomaly. Int Heart J. 2017 Oct 21;58(5):816-819. doi: 10.1536/ihj.16-580. Epub 2017 Sep 30. PubMed PMID: 28966329.

3: Ogino H, Iwamatsu K, Katano K, Nakabayashi S, Yoshida T, Tsuruoka T, Inouye S, Kondo S. New aminothiazolylglycylcephalosporins with a 1,5-dihydroxy-4-pyridone-2-carbonyl group. I. Synthesis and biological activity of cephalosporin derivatives leading to MT0703. J Antibiot (Tokyo). 1990 Feb;43(2):174-88. PubMed PMID: 2179185.

4: Pittman M, Sakai L, Craig R, Joehl R, Milner R. Primary aortoenteric fistula following disseminated bacillus Calmette-Guérin infection: a case report. Vascular. 2012 Aug;20(4):221-4. doi: 10.1258/vasc.2011.cr0315. Epub 2012 Aug 7. Review. PubMed PMID: 22871545.

5: Okamoto R, Hara T, Yoshida T, Orikasa Y, Ogino H, Iwamatsu K, Inouye S. In vitro antimicrobial activity of a novel aminothiazolylglycylcephalosporin, MT0703S, compared with that of ceftazidime, cefoperazone and aztreonam. Drugs Exp Clin Res. 1990;16(4):157-65. PubMed PMID: 2127567.

6: Ogino H, Iwamatsu K, Katano K, Nakabayashi S, Yoshida T, Shibahara S, Tsuruoka T, Inouye S, Kondo S. New aminothiazolylglycylcephalosporins with a 1,5-dihydroxy-4-pyridone-2-carbonyl group. II. Synthesis and antibacterial activity of MT0703 and its diastereomers. J Antibiot (Tokyo). 1990 Feb;43(2):189-98. PubMed PMID: 2179186.