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MedKoo CAT#: 555401

CAS#: 610318-54-2 (free form)

Description: RGX-104, also known as SB 742881, is a liver X receptor beta agonist with potential immunomodulating and antineoplastic activities. Upon oral administration, RGX-104 selectively targets and binds to LXRbeta, thereby activating LXRbeta-mediated signaling, leading to the transcription of certain tumor suppressor genes and the downregulation of certain tumor promoter genes. This particularly activates the expression of apolipoprotein E (ApoE), a tumor suppressor protein, in tumor cells and certain immune cells. This activates the innate immune system, resulting in depletion of immunosuppressive myeloid-derived suppressor cells (MDSCs), tumor cells and endothelial cells in the tumor microenvironment. This reverses immune evasion, enhances anti-tumor immune responses and inhibits proliferation of tumor cells.


Price and Availability

Size Price Shipping out time Quantity
10mg USD 190 Same day
25mg USD 350 Same day
50mg USD 550 Same day
100mg USD 950 Same day
200mg USD 1450 Same day
500mg USD 2650 Same day
1g USD 3650 Same day
2g USD 5450 Same day
5g USD 8950 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-22. Prices are subject to change without notice.

RGX-104 free form, purity > 98%, is in stock.The same day shipping out after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 555401
Name: RGX-104 free form
CAS#: 610318-54-2 (free form)
Chemical Formula: C34H33ClF3NO3
Exact Mass: 595.2101
Molecular Weight: 596.0872
Elemental Analysis: C, 68.51; H, 5.58; Cl, 5.95; F, 9.56; N, 2.35; O, 8.05


Related CAS #: 610318-54-2 (free form)   610318-03-1 (HCl)    

Synonym: RGX-104 free form, RGX-104; RGX104; RGX 104; SB742881; SB-742881; SB 742881;

IUPAC/Chemical Name: (R)-2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]-3-methylpropoxy]phenyl]acetic acid

InChi Key: ZLJZDYOBXVOTSA-XMMPIXPASA-N

InChi Code: InChI=1S/C34H33ClF3NO3/c1-24(18-19-42-29-16-8-10-25(20-29)21-32(40)41)39(22-28-15-9-17-31(33(28)35)34(36,37)38)23-30(26-11-4-2-5-12-26)27-13-6-3-7-14-27/h2-17,20,24,30H,18-19,21-23H2,1H3,(H,40,41)/t24-/m1/s1

SMILES Code: O=C(O)CC1=CC=CC(OCC[C@H](N(CC2=CC=CC(C(F)(F)F)=C2Cl)CC(C3=CC=CC=C3)C4=CC=CC=C4)C)=C1


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Certificate of Analysis:

Safety Data Sheet (SDS):

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


References

1: Aravindhan K, Webb CL, Jaye M, Ghosh A, Willette RN, DiNardo NJ, Jucker BM.
Assessing the effects of LXR agonists on cellular cholesterol handling: a stable
isotope tracer study. J Lipid Res. 2006 Jun;47(6):1250-60. Epub 2006 Mar 27.
PubMed PMID: 16567856.

2: Groot PH, Pearce NJ, Yates JW, Stocker C, Sauermelch C, Doe CP, Willette RN,
Olzinski A, Peters T, d'Epagnier D, Morasco KO, Krawiec JA, Webb CL, Aravindhan
K, Jucker B, Burgert M, Ma C, Marino JP, Collins JL, Macphee CH, Thompson SK,
Jaye M. Synthetic LXR agonists increase LDL in CETP species. J Lipid Res. 2005
Oct;46(10):2182-91. Epub 2005 Jul 16. PubMed PMID: 16024916.