AB928
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    WARNING: This product is for research use only, not for human or veterinary use.

MedKoo CAT#: 207077

CAS#: 2239273-34-6

Description: AB928 is a dual antagonist of the A2aR and A2bR adenosine receptors, leads to greater immune activation and reduced tumor growth when combined with chemotherapy


Price and Availability

Size Price Shipping out time Quantity
100mg USD 1250 2 Weeks
200mg USD 1850 2 Weeks
500mg USD 2950 2 Weeks
1g USD 3650 2 Weeks
2g USD 5850 2 Weeks
Inquire bulk and customized quantity

Pricing updated 2020-10-28. Prices are subject to change without notice.

AB928, purity > 98%, is in stock. Current shipping out time is about 2 weeks after order is received. CoA, QC data and MSDS documents are available in one week after order is received.


Chemical Structure

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Theoretical Analysis

MedKoo Cat#: 207077
Name: AB928
CAS#: 2239273-34-6
Chemical Formula: C23H22N8O
Exact Mass: 426.1917
Molecular Weight: 426.484
Elemental Analysis: C, 64.77; H, 5.20; N, 26.27; O, 3.75


Synonym: AB928 ; AB-928; AB 928;

IUPAC/Chemical Name: 3-[2-Amino-6-[1-[[6-(2-hydroxypropan-2-yl)pyridin-2-yl]methyl]triazol-4-yl]pyrimidin-4-yl]-2-methylbenzonitrile

InChi Key: BUXIAWLTBSXYSW-UHFFFAOYSA-N

InChi Code: InChI=1S/C23H22N8O/c1-14-15(11-24)6-4-8-17(14)18-10-19(28-22(25)27-18)20-13-31(30-29-20)12-16-7-5-9-21(26-16)23(2,3)32/h4-10,13,32H,12H2,1-3H3,(H2,25,27,28)

SMILES Code: N#CC1=CC=CC(C2=NC(N)=NC(C3=CN(CC4=NC(C(C)(O)C)=CC=C4)N=N3)=C2)=C1C


Technical Data

Appearance:
Solid powder

Purity:
>98% (or refer to the Certificate of Analysis)

Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition:
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility:
Soluble in DMSO

Shelf Life:
>3 years if stored properly

Drug Formulation:
This drug may be formulated in DMSO

Stock Solution Storage:
0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code:
2934.99.9001


Additional Information

The structure of AR928 was from below web pages:
https://pubchem.ncbi.nlm.nih.gov/compound/135242184
https://chem.nlm.nih.gov/chemidplus/sid/2239273346


References

1. Preparation of azolopyrimidine for the treatment of cancer and immune related disorders
By Beatty, Joel; Debien, Laurent; Jeffrey, Jenna; Leleti, Manmohan Reddy; Mandal, Debashis; Miles, Dillon; Powers, Jay; Rosen, Brandon; Thomas-Tran, Rhiannon; Sharif, Ehesan. From PCT Int. Appl. (2018), WO 2018136700 A1 20180726.