WARNING: This product is for research use only, not for human or veterinary use.
MedKoo CAT#: 207038
Description: Cantrixil, also known as TRX-E-002-1, is a potent and selective SMETI inhibitor. TRX-E-002-1 Induces c-Jun-Dependent Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo. TRX-E-002-1 may fill the current need for better therapeutic options in the control and management of recurrent ovarian cancer and may help improve patient survival
MedKoo Cat#: 207038
Chemical Formula: C24H24O6
Exact Mass: 408.1573
Molecular Weight: 408.45
Elemental Analysis: C, 70.58; H, 5.92; O, 23.50
This product is not in stock, which may be available by custom synthesis.
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Synonym: Cantrixil; TRX-E-002-1; TRXE-002-1; TRXE-0021; TRXE0021;
IUPAC/Chemical Name: (3R,4S)-3-(4-hydroxy-3,5-dimethoxyphenyl)-4-(4-hydroxyphenyl)-8-methylchroman-7-ol
InChi Key: JFVVPUGGRUGRBJ-AVRDEDQJSA-N
InChi Code: InChI=1S/C24H24O6/c1-13-19(26)9-8-17-22(14-4-6-16(25)7-5-14)18(12-30-24(13)17)15-10-20(28-2)23(27)21(11-15)29-3/h4-11,18,22,25-27H,12H2,1-3H3/t18-,22-/m0/s1
SMILES Code: CC1=C(O)C=CC2=C1OC[C@@H](C3=CC(OC)=C(O)C(OC)=C3)[C@H]2C4=CC=C(O)C=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
The following data is based on the product molecular weight 408.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
|Concentration / Solvent Volume / Mass||1 mg||5 mg||10 mg|
|1 mM||1.15 mL||5.76 mL||11.51 mL|
|5 mM||0.23 mL||1.15 mL||2.3 mL|
|10 mM||0.12 mL||0.58 mL||1.15 mL|
|50 mM||0.02 mL||0.12 mL||0.23 mL|
1: Saif MW, Heaton A, Lilischkis K, Garner J, Brown DM. Pharmacology and
toxicology of the novel investigational agent Cantrixil (TRX-E-002-1). Cancer
Chemother Pharmacol. 2017 Feb;79(2):303-314. doi: 10.1007/s00280-016-3224-2. Epub
2016 Dec 24. Review. PubMed PMID: 28013349; PubMed Central PMCID: PMC5306062.
2: Alvero AB, Heaton A, Lima E, Pitruzzello M, Sumi N, Yang-Hartwich Y, Cardenas
C, Steinmacher S, Silasi DA, Brown D, Mor G. TRX-E-002-1 Induces c-Jun-Dependent
Apoptosis in Ovarian Cancer Stem Cells and Prevents Recurrence In Vivo. Mol
Cancer Ther. 2016 Jun;15(6):1279-90. doi: 10.1158/1535-7163.MCT-16-0005. Epub
2016 Apr 8. PubMed PMID: 27196760.