Harmaline
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MedKoo CAT#: 573235

CAS#: 304-21-2

Description: Harmaline is a beta-carboline alkaloid isolated from seeds of PEGANUM. It is a psychoactive indole with stimulating activities achieved, in part, through inhibition of monoamine oxidases. Harmaline induces tremor in mice through the N-methyl-D-aspartate (NMDA) receptor, at which harmaline may act as an inverse agonist.

Chemical Structure

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Harmaline
CAS# 304-21-2
Instruction

Theoretical Analysis

MedKoo Cat#: 573235
Name: Harmaline
CAS#: 304-21-2
Chemical Formula: C13H14N2O
Exact Mass: 214.11
Molecular Weight: 214.270
Elemental Analysis: C, 72.87; H, 6.59; N, 13.07; O, 7.47

Price and Availability

Size Price Availability Quantity
100mg USD 350 2 Weeks
250mg USD 600 2 Weeks
1g USD 950 2 Weeks
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Synonym: Harmaline

IUPAC/Chemical Name: 3H-Pyrido(3,4-b)indole, 4,9-dihydro-7-methoxy-1-methyl-

InChi Key: RERZNCLIYCABFS-UHFFFAOYSA-N

InChi Code: 1S/C13H14N2O/c1-8-13-11(5-6-14-8)10-4-3-9(16-2)7-12(10)15-13/h3-4,7,15H,5-6H2,1-2H3

SMILES Code: c12c3c([nH]c1C(=NCC2)C)cc(cc3)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 214.27 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Siddiqui H, Tasneem S, Farooq S, Sami A, Rahman AU, Choudhary MI. Harmaline and its Derivatives Against the Infectious Multi-Drug Resistant Escherichia coli. Med Chem. 2017;13(5):465-476. doi: 10.2174/1573406413666170125113832. PubMed PMID: 28124613.

2: Abdulrahman AA, Faisal K, Meshref AA, Arshaduddin M. Low-dose acute vanillin is beneficial against harmaline-induced tremors in rats. Neurol Res. 2017 Mar;39(3):264-270. doi: 10.1080/01616412.2016.1275456. Epub 2017 Jan 18. PubMed PMID: 28095756.

3: Jiang XL, Shen HW, Yu AM. Modification of 5-methoxy-N,N-dimethyltryptamine-induced hyperactivity by monoamine oxidase A inhibitor harmaline in mice and the underlying serotonergic mechanisms. Pharmacol Rep. 2016 Jun;68(3):608-15. doi: 10.1016/j.pharep.2016.01.008. Epub 2016 Feb 5. PubMed PMID: 26977821; PubMed Central PMCID: PMC4848137.