Lytixar HCl

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MedKoo CAT#: 530803

CAS#: Lytixar HCl

Description: Lytixar, also known as LTX-109, is a Synthetic Antimicrobial Peptide, showing activity against Methicillin-Resistant, Vancomycin-Intermediate, Vancomycin-Resistant, Daptomycin-Nonsusceptible, and Linezolid-Nonsusceptible Staphylococcus aureus. LTX-109 demonstrated a MIC range of 2 to 4 μg/ml and dose-dependent rapid bactericidal activity against S. aureus. This activity was not influenced by resistance to other antistaphylococcal agents.

Chemical Structure

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Lytixar HCl
CAS# Lytixar HCl
Instruction

Theoretical Analysis

MedKoo Cat#: 530803
Name: Lytixar HCl
CAS#: Lytixar HCl
Chemical Formula: C43H69N11O3
Exact Mass: 787.56
Molecular Weight: 788.099
Elemental Analysis: C, 65.53; H, 8.83; N, 19.55; O, 6.09

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @medkoo.com or click below button.
Note: Price will be listed if it is available in the future.

Related CAS #: 1166254-80-3 (free base), Lytixar HCl,

Synonym: Lytixar; LTX-109; LTX 109; LTX109; LTX-109 HCl; Lytixar HCl; Lytixar hydrochloride; Lytixar; Voxvoganan;

IUPAC/Chemical Name: L-Argininamide, L-arginyl-2,5,7-tris(1,1-dimethylethyl)-L-tryptophyl-N-(2-phenylethyl)- tetrahydrochloride

InChi Key: LLPGVFVCDNUOCS-VXEPYQPUSA-N

InChi Code: InChI=1S/C43H69N11O3.4ClH/c1-41(2,3)27-23-28-29(35(43(7,8)9)53-34(28)30(24-27)42(4,5)6)25-32(52-37(56)31(44)17-13-20-50-39(46)47)38(57)54(22-19-26-15-11-10-12-16-26)33(36(45)55)18-14-21-51-40(48)49;;;;/h10-12,15-16,23-24,31-33,53H,13-14,17-22,25,44H2,1-9H3,(H2,45,55)(H,52,56)(H4,46,47,50)(H4,48,49,51);4*1H/t31-,32-,33-;;;;/m0..../s1

SMILES Code: [H]Cl.[H]Cl.[H]Cl.[H]Cl.N=C(N)NCCC[C@@H](C(N)=O)N(C([C@H](CC1=C(C(C)(C)C)NC2=C1C=C(C(C)(C)C)C=C2C(C)(C)C)NC([C@@H](N)CCCNC(N)=N)=O)=O)CCC3=CC=CC=C3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

Product Data:
Product Data
Instruction:
View handling instruction
Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 788.099000000000000000000000000000 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Saravolatz LD, Pawlak J, Martin H, Saravolatz S, Johnson L, Wold H, Husbyn M, Olsen WM. Postantibiotic effect and postantibiotic sub-MIC effect of LTX-109 and mupirocin on Staphylococcus aureus blood isolates. Lett Appl Microbiol. 2017 Nov;65(5):410-413. doi: 10.1111/lam.12792. Epub 2017 Sep 19. PubMed PMID: 28802058. 2: Scott RW, Tew GN. Mimics of Host Defense Proteins; Strategies for Translation to Therapeutic Applications. Curr Top Med Chem. 2017;17(5):576-589. Review. PubMed PMID: 27411325. 3: Nilsson AC, Janson H, Wold H, Fugelli A, Andersson K, Håkangård C, Olsson P, Olsen WM. LTX-109 is a novel agent for nasal decolonization of methicillin-resistant and -sensitive Staphylococcus aureus. Antimicrob Agents Chemother. 2015 Jan;59(1):145-51. doi: 10.1128/AAC.03513-14. Epub 2014 Oct 20. PubMed PMID: 25331699; PubMed Central PMCID: PMC4291342. 4: Bojsen R, Torbensen R, Larsen CE, Folkesson A, Regenberg B. The synthetic amphipathic peptidomimetic LTX109 is a potent fungicide that disturbs plasma membrane integrity in a sphingolipid dependent manner. PLoS One. 2013 Jul 12;8(7):e69483. doi: 10.1371/journal.pone.0069483. Print 2013. PubMed PMID: 23874964; PubMed Central PMCID: PMC3709891. 5: Saravolatz LD, Pawlak J, Johnson L, Bonilla H, Saravolatz LD 2nd, Fakih MG, Fugelli A, Olsen WM. In vitro activities of LTX-109, a synthetic antimicrobial peptide, against methicillin-resistant, vancomycin-intermediate, vancomycin-resistant, daptomycin-nonsusceptible, and linezolid-nonsusceptible Staphylococcus aureus. Antimicrob Agents Chemother. 2012 Aug;56(8):4478-82. doi: 10.1128/AAC.00194-12. Epub 2012 May 14. PubMed PMID: 22585222; PubMed Central PMCID: PMC3421571. 6: Isaksson J, Brandsdal BO, Engqvist M, Flaten GE, Svendsen JS, Stensen W. A synthetic antimicrobial peptidomimetic (LTX 109): stereochemical impact on membrane disruption. J Med Chem. 2011 Aug 25;54(16):5786-95. doi: 10.1021/jm200450h. Epub 2011 Jul 26. PubMed PMID: 21732630.